Studies how thinking skills affect walking relearning after stroke
Compares two ways of learning to walk again in older adults with chronic stroke.
Plain-language title generated from the registry record
Registry title: Cognition and Motor Learning Post-stroke
Key facts
- Where
- Los Angeles, United StatesSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 85 years old?
Source: NCT04829071, who can take part
Where in United States
- Center for Health ProfessionsLos Angeles, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Southern California
- Trial code
- NCT04829071
- Record updated
- 10 November 2026
- Original description
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.Read full original descriptionShow less
Cognition as a Moderator of Motor Learning Post-stroke
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
Inclusion: Unilateral stroke; Stroke occurred more than 6 months prior; Paresis confined to one side; Independently ambulatory (including the use of assistive devices); Able to walk for 5 minutes without stopping; Answers no to all general health questions on the PAR-Q+; Willingness to complete study procedures.
Exclusion: Concurrent physical therapy; Brainstem or cerebellar stroke; Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function; Uncontrolled hypertension (>160/110mmHg); Significant cognitive deficit or dementia (<20 on MoCA); Aphasia (expressive, receptive, or global); Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations; Claustrophobia; Inability to give informed consent.