Timed brain and nerve stimulation to study hand use after chronic stroke
Compares timed and random brain and nerve stimulation in adults with chronic stroke.
Plain-language title generated from the registry record
Registry title: Brain State-dependent PCMS in Chronic Stroke
Key facts
- Where
- Austin, United StatesSee the site
- Phase
- Phase 1/2
Where in United States
- University of Texas at AustinAustin, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Texas at Austin
- Trial code
- NCT04830163
- Record updated
- 6 December 2024
- Original description
After stroke, people often have difficulty using their hands. Combined brain and nerve stimulation can strengthen the neural pathways that control hand function. In this study, we will deliver combined brain and nerve stimulation during specific time windows that increase activation of neural pathways underlying hand function. We will compare the effects of combined brain and nerve stimulation during these optimal time windows to the effects of combined brain and nerve stimulation applied during random time windows on post-stroke hand function.Read full original descriptionShow less
Upregulating Corticospinal Function After Stroke Using Brain State-dependent Paired Corticomotoneuronal Stimulation
After stroke, people often have difficulty using their hands. Combined brain and nerve stimulation can strengthen the neural pathways that control hand function. In this study, we will deliver combined brain and nerve stimulation during specific time windows that increase activation of neural pathways underlying hand function. We will compare the effects of combined brain and nerve stimulation during these optimal time windows to the effects of combined brain and nerve stimulation applied during random time windows on post-stroke hand function.
Inclusion: History of stroke > 6 months ago; Presence of residual upper extremity hemiparesis; Willingness to participate; Ability to provide informed consent; Upper extremity Fugl-Meyer score < 66; Mini Mental State Exam score > 24; Discernible and reliable motor-evoked potential (MEP) elicited following single-pulse TMS to the lesioned hemisphere.
Exclusion: History of neurological disease other than stroke; Presence of contraindications to transcranial magnetic stimulation (TMS) or peripheral nerve stimulation (PNS), including: history of adverse reactions to TMS or PNS metal in head, eyes, neck, chest/trunk, or arms, including but not limited to shrapnel, surgical clips, fragments from metalworking, fragments from welding, implanted device, history of frequent and severe headaches or migraines, immediate family history of seizure or epilepsy, personal history of seizure or epilepsy, current, suspected, or planned pregnancy, current or recent (within the last 3 months) use of medications acting on the central nervous system other than selective serotonin reuptake inhibitors (SSRIs), including but not limited to antipsychotic drugs, benzodiazepines, prescription stimulants; Upper extremity Fugl-Meyer score ≥ 66 (66 is the maximum on this scale); Mini Mental State Exam score <= 24; No discernible and reliable MEP elicited following single-pulse TMS to the lesioned hemisphere.