Role of Repeat Resection in Recurrent Glioblastoma
Key facts
- Who runs it
- University of Alberta
- Where
- Canada1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Withdrawn
- Started
- 26 Aug 2021
- Ended
- 24 Mar 2025
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Repeat Surgical Management of Recurrent GBM
- Record updated
- 8 July 2025
- Why it stopped
- Insufficient patient population
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- Age ≥ 18
- Previously histologically confirmed and surgically resected Glioblastoma
- Previous craniotomy for open tumor resection (needle biopsies alone do not count as resection)
- The attending surgeon considers re-operation may improve quality survival
Who cannot take part
- Informed consent not possible
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Patients with recurrent Glioblastoma (GBM) are commonly presented to surgeons, along with the question of whether or not to re-resect the recurrence. There is no Level 1 evidence to support a role for repeat surgery in this context, but a multitude of observational research suggests that repeat surgery may improve quality survival. Unfortunately, these studies all suffer from selection bias.
Read full original descriptionShow less
The goal of this study is to provide a care trial context to help neurosurgeons manage patients presenting with recurrent GBM, with no additional risks, tests, or interventions than what they would normally encounter in routine care. Secondary goals include a test of the hypothesis that repeat resection can improve median overall survival, and that it can increase the number of days of survival outside of a hospital/nursing/palliative care facility.
The 2 groups in the trial
- Repeat Surgical ResectionTreatment being tested
Standard surgical operative management according to local practices.
Treatment: Repeat Surgical Management of Recurrent GBM
- Management Without Re-operationExisting treatment, for comparison
Non-surgical management with standard care according to local practices.
Treatment: Repeat Surgical Management of Recurrent GBM
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Role of Repeat Resection in Recurrent Glioblastoma (4rGBM) Trial: a Randomized Care Trial for Patients With Recurrent GBM
- Record updated
- 8 July 2025