Prosthesis Versus Active Exercise Program in Patients With Glenohumeral Osteoarthritis
Key facts
- Who runs it
- University of Aarhus
- Where
- Denmark, Finland, and Norway7 sites in 3 countriesChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 102 people enrolled
- Started
- 2 Jun 2021
- Ended
- 26 May 2026
- Type of study
- Interventional, 2 groups
- Treatments tested
- TSA-group
- Exercise-group
- Record updated
- 2 July 2026
Who can take part
- Age
- 55 years to 85 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Patients ≥55-85 years
- Moderate-severe primary OA of the glenohumeral joint according to Samilson and Prieto, by measuring the lower osteophyte (32)
- Eligible for surgery with standard TSA
Who cannot take part
- Surgical need for bonegraft
- Previous shoulder fracture (fracture of the proximal humerus or glenoid fracture)
- Planned other upper extremity surgery within six months
- Cancer diagnosis and receiving chemo-, immuno- or radiotherapy
- Neurological diseases affecting shoulder mobility (e.g. disability after previous stroke, multiple sclerosis, Parkinson's, Alzheimer's disease)
- Rheumatoid arthritis or other types of arthritis not diagnosed as primary glenohumeral OA
- Other reasons for exclusion (i.e. mentally unable to participate) or planned absence for more than 14 days in the first 3 months after baseline test
- Unable to communicate in the participating countries respective languages
This trial has no sites in United States.
It has sites in 3 countries. Choose a country to see its sites.
About the trial
What the trial wants to find out
Anatomical total shoulder arthroplasty (TSA) is a well-established treatment for pronounced glenohumeral osteoarthritis. However, the effectiveness of TSA has not been compared to non-surgical treatment in a randomised controlled trial. Shoulder exercises may be an effective treatment for reducing pain and improving function in glenohumeral osteoarthritis. The primary aim of this trial is to examine if TSA followed by standard postsurgical rehabilitation is superior to a 12-week exercise programme in patients with primary glenohumeral OA eligible for unilateral TSA. We hypothesise that surgical intervention followed by standard rehabilitation, results in clinically relevant (18-point, on a scale from 0-100) improvement compared to the exercise intervention.
The 2 groups in the trial
- TSA-groupTreatment being tested
Surgery
- Exercise-groupTreatment being tested
Exercise
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Prosthesis Versus Active Exercise Program in Patients With Glenohumeral Osteoarthritis Eligible For Shoulder Arthroplasty: the ProAct Multicenter, Randomized Controlled Trial
- Record updated
- 2 July 2026