Studying Stroke Patients With Extensive Early Brain Damage Who Receive Clot Removal
Observes adults with acute ischemic stroke who receive endovascular treatment, testing brain scan measures.
Key facts
- Who runs it
- Universitätsklinikum Hamburg-Eppendorf
- Where
- Berlin, Bremen, Hamburg, Kaiserslautern, Marburg, Münster, and Rostock, GermanySee the 7 sitesAlso in 1 other country, 1 site
- Trial code
- Registry title
- Improving Low ASPECTS Stroke Thrombectomy
- Status
- Recruiting
- People taking part
- 500 people, planned
- Started
- 1 May 2023
- Expected to end
- 1 Jan 2028
- Type of study
- Observational, 2 groups
- Treatments tested
- Telephone call on day 90
- Quantification of lesion water uptake by CT densitometry
- Record updated
- 24 May 2023
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with an acute stroke caused by a blocked brain artery, who have a low early CT score (ASPECTS 0-5) and are treated by removing the clot through a catheter. Care stays routine; data are only collected.
- Age
- Older than 18 years
- Sex
- All
- Disease stage
- Acute ischemic stroke, with ASPECTS of 0-5 and a confirmed lasting blockage of the terminal carotid artery, a middle cerebral artery (M1 or M2) or the basilar artery that fits the symptoms.
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Clinical diagnosis of acute ischemic stroke
- ASPECTS of 0-5
- Confirmed diagnosis of persistent occlusion of terminal carotid artery, middle cerebral artery (M1 or M2), or basilar artery consistent with symptoms
- Age >18 years
- Ethic approval in process
Who cannot take part
- none
Where in Germany
Also in 1 other country, 1 site
- Charite University, BerlinBerlin, GermanyContact: Gabriel Broocks, MDEnrolling by invitation
- Hospital Bremen-MitteBremen, GermanyContact: Gabriel Broocks, MDEnrolling by invitation
- University Medical Center Hamburg-EppendorfHamburg, GermanyContact: Gabriel Broocks, MDTaking people
- WestpfalzklinikumKaiserslautern, GermanyContact: Gabriel Broocks, MDEnrolling by invitation
- University Hospital MarburgMarburg, GermanyContact: Andre Kemmling, MDTaking people
- University MünsterMünster, GermanyContact: Gabriel Broocks, MDEnrolling by invitation
- University RostockRostock, GermanyContact: Gabriel Broocks, MDEnrolling by invitation
About the trial
What the trial wants to find out
Improving Low ASPECTS Stroke Thromectomy (I-LAST) is an academic, independent, prospective, multicenter, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Patients receive regular care and data will be collected as part of clinical routine. Baseline clinical and procedural information as well clinical follow-up information during in-hospital stay, and up to 90 days of stroke onset are collected. Data collected include demographics, National Institute of Health Stroke Scale (NIHSS) on admission, pre-treatment ASPECTS, information on timing and success of interventional treatment, procedural complications, intracranial hemorrhage, and functional outcome. Advanced imaging biomarkers will be tested and validated aiming to improve treatment selection and outcome prediction of patients presenting with extensive baseline infarction.
The 2 groups in the trial
- Stroke Patients with an ASPECTS of 0-5 on baseline neuroimaging undergoing thrombectomy
acute stroke patients treated with endovascular treatment combined with thrombolysis or without previous thrombolysis Intervention.
Treatment: Telephone call on day 90 and Quantification of lesion water uptake by CT densitometry
- Stroke Patients with an ASPECTS of 0-5 on baseline neuroimaging not undergoing thrombectomy
acute stroke patients treated with or without thrombolysis
Treatment: Telephone call on day 90 and Quantification of lesion water uptake by CT densitometry
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Improving Low Alberta Stroke Program Early ct Score Stroke Thrombectomy
- Plain-language title
- Studying Stroke Patients With Extensive Early Brain Damage Who Receive Clot RemovalGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 24 May 2023