NCT04886492Enrolling by invitation
CorEvitas SPHERES (Synergy of Prospective Health & Experimental Research for Emerging Solutions) Registry for Neuromyelitis Optica Spectrum Disorder (NMOSD)
Source: ClinicalTrials.gov · Last updated 9 Feb 2026
Brief summary (registry, in English)
This is a Prospective, observational research study for patients with NMOSD under the care of a licensed neurologist. Approximately 800 patients and 35 clinical sites in North America will be recruited to participate with no defined upper limit for either target.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 800 (estimated)
- First submitted
- 10 May 2021
- Start date
- Apr 2021
- Primary completion date
- Jan 2099
- Lead sponsor
- CorEvitas
- Diseases
- Neuromyelitis optica (NMOSD)
- NCT number
- NCT04886492
What you commit to
- Study type: Observational
- Planned participants: 800
- From Apr 2021 to the primary completion date, Jan 2099
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has had a clinically confirmed NMOSD neuro-episode within the 12 weeks prior to enrollment.
- Is participating or planning to participate in a double-blind randomized trial for an NMOSD drug. Note: Concurrent participation in another observational registry or open-label Phase 3b/4 trial is allowed.
- All serology types (APQ4 +/- and MOG +/-) are eligible to enroll in the registry given they meet the 2015 IPND diagnostic criteria.
Who the study is looking for
- Has a diagnosis of NMOSD at the time of enrollment according to the 2015 IPND consensus diagnostic criteria for NMOSD†.
- Age 18 years or older at the time of enrollment.
- Willing to provide Personal Information.
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CorEvitas, LLC Coordinator of this site? Confirm its status | Waltham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.