Tests heat treatment with radiation for cancers that have returned after earlier radiotherapy
Tests heat added to repeat radiation in adults whose cancer has come back.
Plain-language title generated from the registry record
Registry title: Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
Key facts
- Where
- Berlin, GermanySee the site
- Phase
- Phase 2
Where in Germany
- Klinik für Radioonkologie und StrahlentherapieBerlin, GermanyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Charite University, Berlin, Germany
- Trial code
- NCT04889742
- Record updated
- 26 December 2023
- Original description
This study investiagates deep-regional or superficial hyperthermia to enhance radiotherapy or chemoradiation in patients that suffer recurrent disease after previous radiotherapy.Read full original descriptionShow less
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study investiagates deep-regional or superficial hyperthermia to enhance radiotherapy or chemoradiation in patients that suffer recurrent disease after previous radiotherapy.
Inclusion: prior radiotherapy of the treatment side with a treatment dose > 30 Gray (Gy) EQD2 (calculated with alpha/beta value of 9); local/ regional / or oligometastatic tumor recurrence. Maximum number of three macroscopic tumor lesions with at least one of them receiving prior radiotherapy; macroscopic tumor recurrence; side of recurrence is amenable to hyperthermia (abdomen, pelvis, extremities, spine, cervical lymphnodes); planned re-irradiation dose of at least 40 Gy EQD2 (calculated with alpha/beta value of 9).
Exclusion: recurrence is amenable to local ablative radiotherapy (brachytherapy or stereotactic radiotherapy); contraindications for hyperthermia (serious cariovascular disease, ICD or larger implants at the treatment site); psychiatric disorders that impede proper informed consent; >3 macroscopic tumor lesion; brain metastases; recurrence region is not amenable to hyperthermia (lung, liver, mediastinum); serious comorbidities with very limited prognosis quo ad vitam.