Compares two surgery methods for weight regain after gastric bypass
Compares two distal gastric bypass surgeries in adults with severe obesity and weight regain.
Plain-language title generated from the registry record
Registry title: DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass
Key facts
- Where
- Amsterdam, Arnhem, Eindhoven, Gouda, Leeuwarden, Nieuwegein, Roosendaal, and Tilburg, NetherlandsSee the 8 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT04894838, who can take part
Where in Netherlands
- OLVGAmsterdam, NetherlandsTaking people
- Rijnstate HospitalArnhem, NetherlandsTaking people
- Catharina ZiekenhuisEindhoven, NetherlandsNot yet recruiting
- Groene Hart HospitalGouda, NetherlandsNot yet recruiting
- Medisch Centrum LeeuwardenLeeuwarden, NetherlandsTaking people
- St. Antonius HospitalNieuwegein, NetherlandsTaking people
- Bravis HospitalRoosendaal, NetherlandsTaking people
- Elisabeth-TweeSteden HospitalTilburg, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- St. Antonius Hospital
- Trial code
- NCT04894838
- Record updated
- 27 April 2026
- Original description
This study is designed as a prospective multicenter randomized controlled clinical trial comparing two surgical techniques of distal gastric bypass (DGB) in revisional surgery following failed Roux-en-Y gastric bypass. Patients will be randomly allocated 1:1 to A) DGB with lengthening of the BPL (DGB type I) or B) DGB with extended AL (DGB type II). Randomisation is stratified for participating center. The study will be performed in a clinical and out-patient setting with regular visits at 1.5, 3, 6, 12, 18, 24 and 36 months post intervention. The study will be set up as a multicenter study with bariatric centers: St. Antonius hospital, Groene Hart hospital, OLVG, Rijnstate hospital, Elisabeth Twee-steden Hospital, Bravis hospital, Medisch Centrum Leeuwarden, Catharina Hospital.Read full original descriptionShow less
DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass
This study is designed as a prospective multicenter randomized controlled clinical trial comparing two surgical techniques of distal gastric bypass (DGB) in revisional surgery following failed Roux-en-Y gastric bypass. Patients will be randomly allocated 1:1 to A) DGB with lengthening of the BPL (DGB type I) or B) DGB with extended AL (DGB type II). Randomisation is stratified for participating center. The study will be performed in a clinical and out-patient setting with regular visits at 1.5, 3, 6, 12, 18, 24 and 36 months post intervention. The study will be set up as a multicenter study with bariatric centers: St. Antonius hospital, Groene Hart hospital, OLVG, Rijnstate hospital, Elisabeth Twee-steden Hospital, Bravis hospital, Medisch Centrum Leeuwarden, Catharina Hospital.
Inclusion: Age 18-65 years; BMI ≥40 kg/m2 or BMI ≥35 kg/m2 with obesity related comorbidity; Weight regain or insufficient weight loss (EWL<50% or TWL<20%)15,16 following RYGB; Multidisciplinary team screening at one of the bariatric centres; Informed consent and willing to enter the follow-up program.
Exclusion: Severe concomitant disease (such as carcinomas and neurodegenerative disorders); Noncompliance in follow-up or unwilling to undergo surgery; Failed Roux-en-Y gastric bypass due to anatomic, surgical reasons (gastric pouch dilatation >50 mL, gastro-gastric fistula, gastro-jejunostomy); Inflammatory bowel disease, celiac disease, irritable bowel syndrome and other causes of chronic diarrhea; Distalisation of RYGB is technical infeasible (judgment by surgeon); Pregnant women; Inability of reading/understanding and filling out questionnaires.