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Enrolling by invitationPhase 3

Tests long-term safety of inhaled treprostinil in people with lung scarring

Tests inhaled treprostinil's long-term safety in adults with progressive pulmonary fibrosis.

Plain-language title generated from the registry record
Registry title: Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

Key facts

Where
Albuquerque, Ann Arbor, Atlanta, Baltimore, Birmingham, Boston, Charleston, Charlottesville, Chesterfield, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Commack, Dallas, Denver, Durham, Falls Church, Franklin, Gainesville, Greensboro, Greenville, Hershey, Houston, Jackson, Jacksonville, Kansas City, Kissimmee, Knoxville, La Jolla, Los Angeles, Louisville, Madison, Maywood, McAllen, McKinney, Milwaukee, Minneapolis, Murray, Nashville, New Hyde Park, New Orleans, New York, Newport Beach, Oklahoma City, Omaha, Orlando, Philadelphia, Phoenix, Portland, Richmond, Rochester, Rock Hill, Royal Oak, Sacramento, Salt Lake City, San Francisco, Shreveport, Silver Spring, St Louis, Stanford, Tampa, The Bronx, The Woodlands, Tucson, Weston, and Winston-Salem, United StatesSee the 81 sites
Phase
Phase 3

Where in United States

  • University of New Mexico Health Sciences CenterAlbuquerque, United StatesNo longer taking part
  • University of Michigan Int Med Pulmonary and Critical CareAnn Arbor, United StatesNo longer taking part
  • Emory UniversityAtlanta, United StatesNo longer taking part
  • Piedmont Healthcare - AtlantaAtlanta, United StatesNo longer taking part
  • Johns Hopkins Asthma and Allergy CenterBaltimore, United StatesNo longer taking part
  • The University of Alabama at BirminghamBirmingham, United StatesNo longer taking part
  • Brigham and Women's HospitalBoston, United StatesNo longer taking part
  • Massachusetts General HospitalBoston, United StatesNo longer taking part
  • Tufts Medical CenterBoston, United StatesNo longer taking part
  • Medical University of South CarolinaCharleston, United StatesNo longer taking part
  • University of Virginia Health SystemsCharlottesville, United StatesNo longer taking part
  • The Lung Research Center, LLCChesterfield, United StatesNo longer taking part
  • Northwestern Memorial HospitalChicago, United StatesNo longer taking part
  • University of Cincinnati Medical CenterCincinnati, United StatesNo longer taking part
  • Cleveland ClinicCleveland, United StatesNo longer taking part
  • Prisma Health MidlandsColumbia, United StatesNo longer taking part
  • The Ohio State University -Wexner Medical CenterColumbus, United StatesNo longer taking part
  • Stony Brook Advanced Specialty CareCommack, United StatesNo longer taking part
  • Baylor University Medical CenterDallas, United StatesNo longer taking part
  • University of Texas Southwestern Medical CenterDallas, United StatesNo longer taking part
  • National Jewish HealthDenver, United StatesNo longer taking part
  • Duke University Medical CenterDurham, United StatesNo longer taking part
  • Inova Fairfax HospitalFalls Church, United StatesNo longer taking part
  • Clinical Trials Center of Middle TennesseeFranklin, United StatesNo longer taking part
  • University of Florida Health at ShandsGainesville, United StatesNo longer taking part
  • PulmonIx, LLCGreensboro, United StatesNo longer taking part
  • East Carolina UniversityGreenville, United StatesNo longer taking part
  • Penn State Milton S. Hershey Medical CenterHershey, United StatesNo longer taking part
  • Baylor College of MedicineHouston, United StatesNo longer taking part
  • Houston MethodistHouston, United StatesNo longer taking part
  • The University of Texas Health Science Center at HoustonHouston, United StatesNo longer taking part
  • The University of Texas Health Science Center at Houston- McGovern Medical SchoolHouston, United StatesNo longer taking part
  • University Mississippi Medical CenterJackson, United StatesNo longer taking part
  • Ascension St. Vincent'sJacksonville, United StatesNo longer taking part
  • Mayo Clinic FloridaJacksonville, United StatesNo longer taking part
  • University of Kansas Medical CenterKansas City, United StatesNo longer taking part
  • Pulmonary Disease Specialists, PA d/b/a PDS ResearchKissimmee, United StatesNo longer taking part
  • StatCare Pulmonary Consultants, PLLCKnoxville, United StatesNo longer taking part
  • UC San Diego HealthLa Jolla, United StatesNo longer taking part
  • David Geffen School of Medicine at UCLALos Angeles, United StatesNo longer taking part
  • Norton Pulmonary SpecialistsLouisville, United StatesNo longer taking part
  • University of Louisville Healthcare Outpatient CenterLouisville, United StatesNo longer taking part
  • University Hospital and UW Health ClinicsMadison, United StatesNo longer taking part
  • Loyola University Medical CenterMaywood, United StatesNo longer taking part
  • A & A Research Consultants, LLCMcAllen, United StatesNo longer taking part
  • Metroplex Pulmonary and Sleep Center, PAMcKinney, United StatesNo longer taking part
  • Medical College of WisconsinMilwaukee, United StatesNo longer taking part
  • University of MinnesotaMinneapolis, United StatesNo longer taking part
  • Intermountain HealthcareMurray, United StatesNo longer taking part
  • Vanderbilt University Medical CenterNashville, United StatesNo longer taking part
  • Northwell HealthNew Hyde Park, United StatesNo longer taking part
  • Tulane University Medical CenterNew Orleans, United StatesNo longer taking part
  • Weill Cornell Medical CenterNew York, United StatesNo longer taking part
  • NewportNativeMD, Inc.Newport Beach, United StatesNo longer taking part
  • University of Oklahoma Health Sciences CenterOklahoma City, United StatesNo longer taking part
  • Creighton University Clinical Research OfficeOmaha, United StatesNo longer taking part
  • Central Florida Pulmonary Group, PAOrlando, United StatesNo longer taking part
  • Hospital of the University of PennsylvaniaPhiladelphia, United StatesNo longer taking part
  • Temple University HospitalPhiladelphia, United StatesNo longer taking part
  • Thomas Jefferson,Hospital UniversityPhiladelphia, United StatesNo longer taking part
  • Banner-University Medical Center PhoenixPhoenix, United StatesNo longer taking part
  • St. Joseph's Hospital and Medical Center-Norton Thoracic InstitutePhoenix, United StatesNo longer taking part
  • The Oregon ClinicPortland, United StatesNo longer taking part
  • Pulmonary Associates of Richmond, Inc.Richmond, United StatesNo longer taking part
  • Mayo Clinic, Division of Pulmonary and Critical Care MedicineRochester, United StatesNo longer taking part
  • University of Rochester Medical CenterRochester, United StatesNo longer taking part
  • Clinical Research of Rock HillRock Hill, United StatesNo longer taking part
  • Corewell Health William Beaumont HospitalRoyal Oak, United StatesNo longer taking part
  • UC Davis Health Medical CenterSacramento, United StatesNo longer taking part
  • University Of Utah HealthSalt Lake City, United StatesNo longer taking part
  • University of California San FranciscoSan Francisco, United StatesNo longer taking part
  • LSU Health Science Center ShreveportShreveport, United StatesNo longer taking part
  • Adventist HealthCare White Oak Medical CenterSilver Spring, United StatesNo longer taking part
  • Washington University School of MedicineSt Louis, United StatesNo longer taking part
  • Stanford University School of MedicineStanford, United StatesNo longer taking part
  • University of South Florida HealthTampa, United StatesNo longer taking part
  • Montefiore Medical CenterThe Bronx, United StatesNo longer taking part
  • Renovatio ClinicalThe Woodlands, United StatesNo longer taking part
  • University of ArizonaTucson, United StatesNo longer taking part
  • Cleveland Clinic FloridaWeston, United StatesNo longer taking part
  • Southeastern Research CenterWinston-Salem, United StatesNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
United Therapeutics
Trial code
NCT04905693
Record updated
19 October 2026
Original description
Study RIN-PF-302 is designed to evaluate the long-term safety and tolerability of inhaled treprostinil in subjects with idiopathic pulmonary fibrosis or progressive pulmonary fibrosis.Read full original descriptionShow less

An Open-label Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease (TETON-OLE)

Study RIN-PF-302 is designed to evaluate the long-term safety and tolerability of inhaled treprostinil in subjects with idiopathic pulmonary fibrosis or progressive pulmonary fibrosis.

Inclusion: Subject gives voluntary informed consent to participate in the study; The subject participated in Study RIN-PF-301, Study RIN-PF-303, or Study RIN-PF-305 and remained on study drug and completed all scheduled study visits or was enrolled in Study RIN-PF-301, Study RIN-PF-303, or Study RIN-PF-305 at the time that the study or study subject was discontinued by the Sponsor for reasons other than safety; Women of childbearing potential must be non-pregnant (as confirmed by a urine pregnancy test at OLE Entry Visit) and non-lactating, and will agree to abstain from intercourse (when it is in line with their preferred and usual lifestyle) or use 2 medically acceptable, highly effective forms of contraception for the duration of the study, and at least 30 days after discontinuing study drug; Males with a partner of childbearing potential must agree to use a condom for the duration of treatment and for at least 48 hours after discontinuing study drug; In the opinion of the Investigator, the subject is able to communicate effectively with study personnel, and is considered reliable, willing, and likely to be cooperative with protocol requirements, including attending all study visits.

Exclusion: Use of any other investigational drug/device or participation in any investigational study in which the subject received a medical intervention (ie, procedure, device, medication/supplement). Subjects participating in non-interventional, observational, or registry studies are eligible; Subject is pregnant or lactating; In the opinion of the Investigator, enrollment in Study RIN-PF-302 would represent a risk to the subject's overall health.

ClinicalTrials.gov NCT04905693