NCT04935684RecruitingPhase 2
Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantation
Faecal Microbiota Transplantation for Prevention of Graft-versus-host Sisease After Allogeneic Stem Cell Transplantation for Haematological Malignancies
Source: ClinicalTrials.gov · Last updated 21 Sept 2026
Brief summary (registry, in English)
The aim of this study is to assess the Fecal Microbiota Transplantation (FMT) efficacy in the prevention of allogeneic hematopoietic stem cell transplantation (allo-HSCT) complications and particularly Graft versus Host Disease (GvHD). The hypothesis of this study is that allogeneic FMT may improve outcomes of these patients.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 1 Jun 2021
- Start date
- 20 Dec 2022
- Primary completion date
- May 2030
- Lead sponsor
- University Hospital, Clermont-Ferrand
- Diseases
- Acute lymphoblastic leukaemia, Hodgkin lymphoma, Myelodysplastic syndromes, Chronic lymphocytic leukaemia, Multiple myeloma
- NCT number
- NCT04935684
- EudraCT number
- 2020-000673-24
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 150
- From 20 Dec 2022 to the primary completion date, May 2030
- 20 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medical history of another progressive cancer or occurrence in the 3 previous years (excluding basal cell carcinoma)
Other illness
- Presence of a simultaneous serious and uncontrolled disease (severe cardiac, renal, hepatic or respiratory failure, severe sepsis)
Other
- Status of tumor progression at the time of allo-HSCT
- Inability to understand the protocol (linguistic barrier, cognitive difficulties)
- Fecal incontinence
- Participation in another clinical trial studying an allograft procedure including the type of graft, the type of immunosuppression, a preventive or a curative treatment of GvHD, or studying the effectiveness of a FMT in another indication.
- Pregnant women
- Patient under guardianship, curatorship or protection of justice
Who the study is looking for
- Patient aged 18 or over
- Men and women
- Patients affiliated with a social-security organization
- Patients undergoing a myelo-ablative allo-HSCT for a controlled haematologic malignant disease, with peripheral stem cells, whatever the type of donor (except cord blood)
- Signed and dated informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service d'Hématologie Clinique et Thérapie Cellulaire CHU Amiens Picardie - Site Sud Coordinator of this site? Confirm its status | Amiens | France | Not yet recruiting |
| Service Maladies du sang CHU Angers Coordinator of this site? Confirm its status | Angers | France | Not yet recruiting |
| Hématologie clinique CHU Besançon Coordinator of this site? Confirm its status | Besançon | France | Not yet recruiting |
| Plateforme d'Investigation Clinique / Centre d'Investigation Clinique - Inserm 1405, CHU Gabriel Montpied Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Recruiting |
| Service de thérapie Cellulaire et d'Hématologie Clinique Adulte CHU Estaing - Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Not yet recruiting |
| Service hématologie CHU Grenoble Coordinator of this site? Confirm its status | Grenoble | France | Not yet recruiting |
| Service des Maladies du sang Hôpital HURIEZ, CHRU de Lille Coordinator of this site? Confirm its status | Lille | France | Not yet recruiting |
| Service de thérapie cellulaire et l'hématologie clinique adulte CHU Limoges Coordinator of this site? Confirm its status | Limoges | France | Recruiting |
| Service d'Hématologie Centre Hospitalier Lyon Sud Coordinator of this site? Confirm its status | Lyon | France | Not yet recruiting |
| Service d'Hématologie et de Médecine interne Hôpital Brabois CHRU Nancy Coordinator of this site? Confirm its status | Nancy | France | Not yet recruiting |
| Service d'Hématologie Clinique CHU Nantes Coordinator of this site? Confirm its status | Nantes | France | Not yet recruiting |
| Service d'hématologie clinique, département de greffe de moelle CHU Nice Coordinator of this site? Confirm its status | Nice | France | Not yet recruiting |
| Service d'Hématologie Adultes Hôpital Necker Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| Service d'Hématologie clinique Hôpital Pitié-Salpêtrière Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| Service d'hématologie greffe Hôpital St Louis Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| Hématologie clinique et thérapie cellulaire Hôpital Haut-Lévèque Coordinator of this site? Confirm its status | Pessac | France | Not yet recruiting |
| Service d'hématologie greffe Hôpital St Louis Coordinator of this site? Confirm its status | Poitiers | France | Not yet recruiting |
| Département d'hématologie CAC Rouen Coordinator of this site? Confirm its status | Rouen | France | Not yet recruiting |
| Hématologie clinique Institut de Cancérologie de la Loire Coordinator of this site? Confirm its status | Saint-Etienne | France | Not yet recruiting |
| IUC T - Oncopôle Coordinator of this site? Confirm its status | Toulouse | France | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.