NCT04938167Active, not recruiting
Preductal Oxygen Saturation Target in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure or Pulmonary Hypertension
Preductal Oxygen Saturation Target in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure or Pulmonary Hypertension (POST-IT)
Source: ClinicalTrials.gov · Last updated 8 Apr 2026
Brief summary (registry, in English)
The purpose of this research is to evaluate two oxygen saturation goals for newborns with pulmonary hypertension. Participation in this research will involve random assignment to one of two oxygen saturation goals, review of the medical record and targeted echocardiograms.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 54 (actual)
- First submitted
- 16 Jun 2021
- Start date
- 1 Aug 2021
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- University of California, Davis
- NCT number
- NCT04938167
What you commit to
- Study type: Interventional
- Participants enrolled: 54
- From 1 Aug 2021 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- A condition or congenital anomaly known to be lethal (high likelihood of death during infancy) - e.g., trisomy 18 or trisomy 13
- Congenital heart disease other than ASD/PFO, PDA or VSD (single or multiple defects) \< 2 mm.
Other
- \< 32 weeks gestation at birth (31 6/7 or lower)
- Weight \< 2000 g at the time of enrollment
- Severe HRF with OI \> 35 or SpO2 \< 75% on FiO2 = 1.0 on mechanical ventilation for \> 60 minutes in spite of correction of reversible factors such as pneumothorax
Who the study is looking for
- Corrected gestational age (postmenstrual age) \> 34 6/7 weeks
- postnatal age ≤ 28 d
- on respiratory support with invasive mechanical ventilation, non-invasive ventilation, CPAP or high flow nasal cannula (defined as flow rates ≥ 2 LPM with a humidifier), inspired oxygen concentration, FiO2 ≥ 0.3
- and echocardiography shows any finding suggestive of PH (or score \> 0 for PH in table 2).
- Infants with congenital diaphragmatic hernia (CDH), Down syndrome, hypoxic ischemic encephalopathy (HIE) on therapeutic hypothermia and patent ductus arteriosus (PDA), patent foramen ovale/atrial septal defect (PFO/ASD) and ventricular septal defect (VSD) (single or multiple) \< 2 mm can be included in the study.
Age in the registry: 0 days to 28 days · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California - Davis Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.