Opioid Reduction in Orthopaedic Surgery (OREOS) - Knees
Key facts
- Who runs it
- Kim Madden
- Where
- Canada1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 102 people enrolled
- Started
- 9 Mar 2022
- Ended
- 14 Jul 2024
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Multicomponent opioid reduction and pain management pathway
- Standard care
- Record updated
- 3 December 2024
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Adult (18+)
- Undergoing elective total knee arthroplasty (TKA) for knee arthritis
- Can use a simple electronic (phone or tablet) device
- Provide informed consent to participate
Who cannot take part
- Revision surgery
- Simultaneous bilateral arthroplasties
- Unable to consent (e.g., cognitive disability or substantial language barrier without a support person)
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery. Doctors often prescribe opioid medications for pain after surgery (e.g. Percocet, hydromorphone, codeine). These medications can be helpful for some people, but they can also be dangerous, particularly when used for a long time. Many patients don't like the way opioids make them feel and would prefer alternative pain management strategies. Some people become addicted to opioids, have a difficult time reducing the dose of opioids, or have lasting health problems after using them.
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People in this study will be randomized to either have usual care or a new pathway designed to improve pain control and decrease opioid use after knee replacements. This study will have an intervention coordinator who will assess patients before surgery and who will follow up with patients regularly after surgery to make sure their pain is controlled and to avoid long-term opioid use. This study will use education, physiotherapy, psychological therapy, ice/cold, and non-opioid pain medications. As pain medications may work differently in different patients, the coordinator will check on each patient to look for pain control and assist to reduce the amount of opioids used after surgery.
This study will help people have safer and more effective pain management after surgery which may lead to better recovery, higher satisfaction, and a lower risk of being harmed by opioids after surgery.
The 2 groups in the trial
- Standard care groupExisting treatment, for comparison
This group will receive standard perioperative care, surgical treatment, and pain medications.
Treatment: Standard care
- Opioid reduction groupTreatment being tested
Patients will participate in a multicomponent pathway coordinated by a trained coordinator who will facilitate patient participation and engagement with each interventional component.
Treatment: Multicomponent opioid reduction and pain management pathway
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Opioid Reduction in Orthopaedic Surgery (OREOS): a Feasibility Randomized Controlled Trial in Knee Replacement Patients
- Record updated
- 3 December 2024