Testing combined brain and exercise training in people with chronic heart failure
Tests combined brain and physical exercise training in adults with heart failure.
Plain-language title generated from the registry record
Registry title: Comparing the Effects of Combining Cognitive and Physical Exercise Training on Cognition, and Cerebral Blood Flow Regulation in Men and Women With Chronic Heart Failure
Key facts
- Where
- Montreal, CanadaSee the site
Where in Canada
- Preventive medicine and physical activity centre (centre EPIC), Montreal Heart InstituteMontreal, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Montreal Heart Institute
- Trial code
- NCT04970888
- Record updated
- 2 December 2025
- Original description
The objective of this project is to assess the effects of combined physical exercise and cognitive training interventions on cognitive and brain health in patients with heart failure (HF). Also, the role of sex on the effects of the interventions will be assessed.Read full original descriptionShow less
Comparing the Effects of Combining Cognitive and Physical Exercise Training on Cognition, and Cerebral Blood Flow Regulation in Men and Women With Chronic Heart Failure
The objective of this project is to assess the effects of combined physical exercise and cognitive training interventions on cognitive and brain health in patients with heart failure (HF). Also, the role of sex on the effects of the interventions will be assessed.
Inclusion: Age ≥ 50 years old; Stable chronic HF on maximally tolerated background treatment for at least 2 months (stable therapy with ACE-I, ARBs and MRA for at least 2 months), regardless of LVEF; with no limitation of physical activity in ordinary physical activity (i.e. NYHA class I), moderate symptoms (i.e. NYHA class II) or marked limitation in activity (i.e. NYHA class III); Able to perform cognitive and physical training.
Exclusion: Acute cardiovascular event 1 month prior to randomization, including emergency visit or hospitalization for decompensated HF, acute myocardial infarction, stroke, and transient ischemic attack; Planned cardiovascular intervention within 6 months (implantation of any cardiac device, cardiac revascularization, heart transplantation); Contraindications for exercise testing (e.g., uncorrected severe aortic or carotid stenosis, severe pulmonary hypertension, severe non-revascularizable coronary disease including left main coronary stenosis, significant myocardial ischemia or arrhythmia during low-intensity exercise, acute HF); Severe respiratory disease; Non-cardiopulmonary limitation to exercise (e.g., arthritis, claudication or any peripheral neurological disease including other neurodegenerative diseases such as disabling Parkinson); Uncontrolled diabetes or untreated thyroid dysfunction; Current or recent malignancy with life expectancy < 1 year; Severe exercise intolerance; Chronic hemodialysis or peritoneal dialysis; Unable to read the informed consent form or unable to understand the oral explanations provided by the assessor.