NIRS vs TCD for Cerebrovascular Autoregulation During Non-cardiac Surgery
Key facts
- Who runs it
- Universitätsklinikum Hamburg-Eppendorf
- Where
- Germany1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 509 people enrolled
- Started
- 9 Aug 2021
- Ended
- 19 Sept 2024
- Type of study
- Observational
- Treatments tested
- Continuous assessment of cerebrovascular autoregulation with NIRS and TCD
- Record updated
- 2 October 2025
Who can take part
- Age
- 18 years to 99 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Age ≥ 18 years
- Elective surgery with a minimum duration of 120 minutes
- General anesthesia
- expected blood loss > 500 ml
Who cannot take part
- Temporal bone window failure (substudy 1)
- Cerebrovascular disease
- Cardiac surgery
- Neurosurgery
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Postoperative neurocognitive disorders (NCD) are of high priority in perioperative management. The risk of suffering from NCD after surgery may be increased due to perioperative impairment of cerebrovascular autoregulation and thereby inadequate cerebral perfusion. Cerebrovascular autoregulation refers to the ability of cerebral arterioles to ensure constant cerebral blood flow independently of fluctuations in systemic blood pressure.
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Cerebrovascular autoregulation can be measured based on mean arterial pressure (MAP) and a surrogate for cerebral blood flow using the correlation method. Until today, measurement of cerebral blood flow velocity assessed with transcranial Doppler sonography (TCD) is most commonly used as a non-invasive surrogate for cerebral blood flow. Alternatively, cerebral oxygenation measured with near-infrared spectroscopy (NIRS) can be used as another surrogate.
The study includes three substudies:
1. To compare NIRS and TCD for the assessment of perioperative cerebrovascular autoregulation in patients undergoing major non-cardiac surgery with an increased risk of bleeding. 2. To compare MAP for optimal cerebrovascular autoregulation before induction of general anesthesia with MAP for optimal cerebrovascular autoregulation during or after general anesthesia. 3. To analyze the association between the time-weighted average MAP below the MAP for optimal cerebrovascular autoregulation and postoperative NCD.
Treatments tested
- Continuous assessment of cerebrovascular autoregulation with NIRS and TCD
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Cerebrovascular Autoregulation During Major Non-cardiac Surgery - a Comparison Between Near Infrared Spectroscopy and Transcranial Doppler Sonography
- Record updated
- 2 October 2025