Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
Key facts
- Where
- Dallas, Pittsburgh, and Richmond, United StatesSee the 3 sites
- Phase
- Phase 2/3
Where in United States
- VA North Texas Health Care System Dallas VA Medical Center, Dallas, TXDallas, United StatesTaking people
- VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PAPittsburgh, United StatesTaking people
- Hunter Holmes McGuire VA Medical Center, Richmond, VARichmond, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT04982419
- Record updated
- 15 December 2025
- Original description
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in in patients with congestive heart failure undergoing cardiac catheterization and/or percutaneous coronary intervention.Read full original descriptionShow less
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in in patients with congestive heart failure undergoing cardiac catheterization and/or percutaneous coronary intervention.
Inclusion: Age 18 years; Diagnosis of heart failure with reduced LVEF <50%; Pre-procedure intravenous normal saline fluid restriction status; Society for Cardiovascular Angiography and Interventions (SCAI) AKI risk score (>1%); Referral for coronary angiogram and/or PCI; Suspected stable coronary artery disease or acute coronary syndrome.
Exclusion: Kidney transplant; Prior exposure to contrast media within 72hrs preceding coronary angiography; Upper limb peripheral arterial disease; Renal disease requiring dialysis; Inability to give informed consent; Unstable BP (SBP > 200 or <80 mmHg) at the time of enrolment; Unavailability of at least one arm for RIPC/Sham-RIPC application; Pregnancy; Prisoner.