Compares two talk therapies for long-lasting, hard-to-treat depression in hospital patients
Compares two talk therapies, CBASP and Behavioral Activation, in hospital patients with treatment-resistant depression.
Plain-language title generated from the registry record
Registry title: A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
Key facts
- Where
- Berlin, Bonn, Hanover, Jena, Lübeck, Marburg, München, and Tübingen, GermanySee the 8 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT04996433, who can take part
Where in Germany
- Charité - University Medicine BerlinBerlin, GermanyTaking people
- Universitätsklinikum BonnBonn, GermanyTaking people
- Medizinische Hochschule HannoverHanover, GermanyNo longer taking part
- Universitätsklinikum JenaJena, GermanyTaking people
- Universität zu LübeckLübeck, GermanyTaking people
- Universitätsklinikum MarburgMarburg, GermanyTaking people
- Klinikum der Universität MünchenMünchen, GermanyTaking people
- Universitätsklinikum TübingenTübingen, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Greifswald
- Trial code
- NCT04996433
- Record updated
- 26 May 2026
- Original description
The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.Read full original descriptionShow less
Cognitive Behavioral Analysis System of Psychotherapy (CBASP) vs. Behavioral Activation (BA) in Persistently Depressed Treatment-resistant Inpatients: Efficacy, Moderators, and Mediators of Change
The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.
Inclusion: Primary DSM-5 diagnosis of PDD (300.4, 296.2x, 296.3x); Total Hamilton Depression Rating Scale (HDRS-24) Score ≥ 20; Treatment-resistance (TR) (defined by the ATHF-SF or medication intolerance or one psychotherapy at least 25 sessions by a certified therapist in the current episode); Sufficient knowledge of the German language; Written informed consent.
Exclusion: Previous CBASP or BA treatment within the last year; Bipolar I or II disorder; Active substance use disorders (abstinence shorter than 6 months); Schizophrenia spectrum and other psychotic disorders; Antisocial personality disorder; Inability to tolerate CBASP or BA (e.g., organic brain disorders, severe cognitive deficits); Acute suicidality (HRSD item 3 > 2 or agreement with C-SSRS item 4 and/or item 5); Inability to participate in dayclinic or outpatient continuation treatment; Participation in another (psycho)therapeutic study of an interventional nature.