Tracking Brain Recovery in Infants With Perinatal Stroke
Follows infants with perinatal stroke over time, using brain scans, stimulation and motor tests.
Plain-language title generated from the registry record
Registry title: Baby Brain Recovery Study
Key facts
- Where
- Madison, United StatesSee the site
Where in United States
- University of Wisconsin School of Medicine and Public HealthMadison, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Wisconsin, Madison
- Trial code
- NCT05013736
- Record updated
- 18 September 2026
- Original description
This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with perinatal stroke.Read full original descriptionShow less
Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery Through Neuroexcitability, Neuroimaging and Motor Development
This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with perinatal stroke.
65 participants will be recruited and complete 1 visit at time point 1 (0-2 months), and 2 visits at each timepoints 2-5 with windows of +- 4 weeks (3-6 months, 12 months, 18 months and 24 months). Visits will consist of Magnetic Resonance Imaging (MRI) assessment during the child's natural sleep, Transcranial Magnetic Stimulation (TMS), and Motor Behavioral Assessments.
Main Inclusion Criteria:; Infants with corrected gestational age between term age and 24 months of age at study enrollment; Radiologically-confirmed acute unilateral or bilateral brain lesions, including perinatal stroke, neonatal hemorrhagic or thrombotic stroke, involving the motor cortex and/or subcortical structures, and intracranial hemorrhage, involving the motor cortex and/or subcortical white matter, periventricular leukomalacia, and hypoxic-ischemic encephalopathy (HIE); English-speaking parent/legal guardian (able to provide consent); Main Exclusion Criteria:; Other neurologic disorders unrelated to perinatal stroke/brain bleed/HIE; Metabolic disorders; Disorders of Cellular Migration and Proliferation; Acquired Traumatic Brain Injury.