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Quality of life after carbon ions, surgery or protons for pelvic sarcoma

Compares carbon ions, protons and surgery for pelvic bone sarcomas.

Key facts

Who runs it
Mayo Clinic
Where
Jacksonville, Rochester, and Scottsdale, United StatesSee the 3 sites
Trial code
Registry title
Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone
Status
Recruiting
People taking part
72 people, planned
Started
20 Jan 2022
Expected to end
30 Aug 2031
Type of study
Observational
Treatments tested
  • Electronic Health Record Review
  • Quality-of-Life Assessment
Record updated
13 March 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for people aged 15 or older with a newly diagnosed sarcoma of the pelvic bone that has not spread to other parts of the body.

Age
15 years or older
Sex
Men and women can join.
Disease stage
Newly diagnosed pelvic chordoma, chondrosarcoma, osteosarcoma, Ewing sarcoma with bone involvement, rhabdomyosarcoma (RMS) with bone involvement, or non-RMS soft tissue sarcoma with bone involvement. No distant metastases (spread) on examination and imaging.
Earlier treatment
No earlier radiation to the sarcoma area that would need re-irradiation. Chemotherapy per institutional guidelines is allowed.

Main reasons for not taking part

  • Treatment given only to ease symptoms (palliative)
  • Recurrent (returned) disease
  • Distant metastases
  • Benign pelvic bone tumors
  • Pregnant or nursing women

The registry criteria, word for word

Show all 15 criteriaShow less

Who can take part

  • Males and females >= 15 years of age
  • Newly diagnosed, histologic confirmation of pelvic chordoma, chondrosarcoma, osteosarcoma, Ewing sarcoma with bone involvement, rhabdomyosarcoma (RMS) with bone involvement or non-RMS soft tissue sarcoma with bone involvement
  • No evidence of distant sarcoma metastases as determined by clinical examination and any form of imaging
  • Eastern Cooperative Oncology Group (ECOG) performance status (PS) =< 2
  • Patients capable of childbearing must agree to use adequate contraception
  • Ability to complete questionnaire(s) by themselves or with assistance
  • Ability to provide written informed consent
  • Chemotherapy per institutional guidelines is allowed

Who cannot take part

  • Patients receiving palliative treatment
  • Previous radiation therapy to the site of the sarcoma or area surrounding it such that it would be partially or completely encompassed by the radiation volume needed to treat the current sarcoma. In other words, treatment on this study would require re-irradiation of tissues
  • Recurrent disease
  • Males and females < 15 years of age
  • Patients with distant sarcoma metastases
  • Benign pelvic bone histologies
  • Any of the following:; Pregnant women; Nursing women; Men or women of childbearing potential who are unwilling to employ adequate contraception

Where in United States

  • Mayo Clinic in FloridaJacksonville, United StatesContact: Clinical Trials Referral OfficeTaking people
  • Mayo Clinic in RochesterRochester, United StatesContact: Clinical Trials Referral OfficeTaking people
  • Mayo Clinic in ArizonaScottsdale, United StatesContact: Clinical Trials Referral OfficeTaking people

About the trial

What the trial wants to find out

This study compares carbon ion therapy, surgery, and proton therapy to determine if one has better disease control and fewer side effects. There are three types of radiation treatment used for pelvic bone sarcomas: surgery with or without photon/proton therapy, proton therapy alone, and carbon ion therapy alone. The purpose of this study is to compare quality of life among patients treated for pelvic bone sarcomas across the world, and to determine if carbon ion therapy improves quality of life compared to surgery and disease control compared with proton therapy.

The group in the trial

  • Observational (questionnaires, medical record review)

    Patients complete quality of life questionnaires over 20 minutes at baseline (before any therapy), 2-4 and 5-9 months after completion of therapy, and then annually for up to 5 years. Patients' medical records are also reviewed.

    Treatment: Electronic Health Record Review and Quality-of-Life Assessment

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone
Plain-language title
Quality of life after carbon ions, surgery or protons for pelvic sarcomaGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
13 March 2026