Investigating Distress Tolerance in Adults With Tourette Syndrome
Key facts
- Who runs it
- Johns Hopkins University
- Where
- Baltimore, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 9 people enrolled
- Started
- 2 Jun 2022
- Ended
- 28 May 2024
- Type of study
- Interventional
- Treatments tested
- Distress Tolerance Skills Training
- Record updated
- 7 June 2024
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 15 criteriaShow less
Who cannot take part
- history of cardiovascular disorder
- history of fainting or seizures
- history of frostbite
- history of Reynaud's phenomenon
- open cut or sore on hand to be immersed
- fracture to the limb to be immersed
- inability to complete rating scales
- inability to attend study visits
Other criteria
- Participants will be eligible for participation if the following inclusion criteria are met:
- at least 18 years of age
- have moderate tic severity or greater as evidenced by a YGTSS Total Tic Score greater than 14 (>9 for adults with motor or vocal tics only)
- exhibit a tic frequency of at least one visible tic per minute
- be fluent in English
- have a total premonitory urge for tics scale (PUTS) total score greater than 17 at Visit 2
- have a total DTS score greater than 30 at Visit 2
Where in United States
- Johns Hopkins University School Of MedicineBaltimore, United StatesNo longer taking part
About the trial
What the trial wants to find out
Although behavior therapy is recognized as a first-line intervention for Tourette's Disorder (TD), less than 40% of adults with TD respond to this evidence-based treatment. Limited tolerance for aversive premonitory urges and affective states that accompany tics may be one likely factor that impedes behavior therapy outcomes. This study examines the relationship between distress tolerance and tic inhibition among adults with TD, and investigates the mechanism and effect of therapeutic skills training to enhance distress tolerance abilities. Findings will determine the optimal approach to enhance distress tolerance among adults with TD and ultimately lead to better behavior therapy outcomes.
The group in the trial
- Distress Tolerance Skills TrainingTreatment being tested
Distress tolerance skills training is a multicomponent intervention drawn from third-wave cognitive-behavioral therapy (CBT) protocols.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 7 June 2024