Nurse-led support and exercise for vulnerable people with lung cancer
Tests a nurse-led program with symptom tracking and exercise in adults with lung cancer.
Plain-language title generated from the registry record
Registry title: Navigate - Improving Survival and Quality of Life in Vulnerable Lung Cancer Patients
Key facts
- Where
- Aalborg, Herning, Odense, Roskilde, Sønderborg, and Vejle, DenmarkSee the 6 sites
Where in Denmark
- Aalborg University HospitalAalborg, DenmarkTaking people
- Gødstrup HospitalHerning, DenmarkTaking people
- Odense University HospitalOdense, DenmarkTaking people
- Zealand University HospitalRoskilde, DenmarkTaking people
- Sønderborg SygehusSønderborg, DenmarkTaking people
- Vejle SygehusVejle, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Zealand University Hospital
- Trial code
- NCT05053997
- Record updated
- 29 December 2025
- Original description
Half of patients with lung cancer face a limited life span of one-year survival, which is characterized by severe physical and psychological symptoms. Differences in stage, comorbidity but also treatment may explain a large proportion of the social inequality in lung cancer survival. Some vulnerable patients may not receive first line treatment as planned either due to poor performance status or if they are not able to adhere to treatment appointments. Knowing how to navigate the health system may be a barrier preventing vulnerable patients in receiving optimal treatment. The primary aim of this randomised, controlled trial is to test whether a nurse-led individually tailored program including systematic screening of symptoms using PROs and a physical training program will significantly improve a composite outcome of survival and quality of life as the primary outcome among vulnerable lung cancer patients compared with standard care. Secondary outcomes include adherence to cancer treatment, symptom burden and overall survival.Read full original descriptionShow less
NAVIGATE - Improving Survival and Quality of Life in Vulnerable Lung Cancer Patients Through Nurse Navigation, Symptom Monitoring and Exercise: Study Protocol for a Multicenter Randomized Controlled Trial
Half of patients with lung cancer face a limited life span of one-year survival, which is characterized by severe physical and psychological symptoms. Differences in stage, comorbidity but also treatment may explain a large proportion of the social inequality in lung cancer survival. Some vulnerable patients may not receive first line treatment as planned either due to poor performance status or if they are not able to adhere to treatment appointments. Knowing how to navigate the health system may be a barrier preventing vulnerable patients in receiving optimal treatment. The primary aim of this randomised, controlled trial is to test whether a nurse-led individually tailored program including systematic screening of symptoms using PROs and a physical training program will significantly improve a composite outcome of survival and quality of life as the primary outcome among vulnerable lung cancer patients compared with standard care. Secondary outcomes include adherence to cancer treatment, symptom burden and overall survival.
Inclusion: Age ≥ 18 years of age; Diagnosed with NSCLC at all stages regardless of treatment intension at the participating departments; Performance status ≤ 2; Vulnerable according to pre-defined criteria.
Exclusion: Severe untreated psychiatric disorder (e.g. psychosis) or cognitive problems (e.g. dementia) preventing informed consent; Not able to receive treatment; Not able to read and understand Danish -.