Tests two medicines for heart vessel health in women with endometriosis
Tests simvastatin and bazedoxifene with estrogens in women with endometriosis.
Plain-language title generated from the registry record
Registry title: Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
Key facts
- Where
- New Haven, United StatesSee the site
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT05059626, who can take part
Where in United States
- The John B. Pierce LaboratoryNew Haven, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Penn State University
- Trial code
- NCT05059626
- Record updated
- 27 July 2026
- Original description
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis.Read full original descriptionShow less
Mechanisms and Interventions Addressing Accelerated Cardiovascular Disease Risk in Women With Endometriosis
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis.
Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Inclusion: Women between the ages of 18 and 45 years with endometriosis (diagnosis by prior laparoscopy by subject's own physician <10 years prior, and reported by the subject to the researchers); Tylenol if the subject has acute pain is allowed; IUD contraceptive use (copper or levonogestrel) is allowed.
Exclusion: Taking pharmacotherapy that could alter peripheral vascular control (e.g. insulin sensitizing, cardiovascular medications); Taking illicit and/or recreational drugs; Rash, skin disease, disorders of pigmentation, known skin allergies; Diagnosed or suspected metabolic or cardiovascular disease; Known allergy to latex or investigative substances; Diabetes (HbA1C .6.5%); Persistent unexplained elevations of serum transaminases; Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.); BP>140/90; Pregnancy; Breastfeeding; Abnormal liver function.