NCT05063539CompletedPhase 2
A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease
Assessment of Safety, Tolerability, and Efficacy of LY3372689 in Early Symptomatic Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 12 Jun 2026
Brief summary (registry, in English)
The purpose of this study is to assess the safety, tolerability and effect of study drug LY3372689 in participants with early symptomatic Alzheimer's Disease
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 327 (actual)
- First submitted
- 14 Sept 2021
- Start date
- 16 Sept 2021
- Primary completion date
- 9 Jul 2024
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Frontotemporal dementia, Alzheimer disease
- NCT number
- NCT05063539
- EU CT number
- 2024-512295-36-00
- EudraCT number
- 2021-000170-29
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 327
- From 16 Sept 2021 to the primary completion date, 9 Jul 2024
- 69 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have known allergies to LY3372689, related compounds, or any components of the formulations
Other
- Contraindication to MRI or PET scans
Who the study is looking for
- Gradual and progressive change in memory function reported by participants or informants for ≥ 6 months
- MMSE score of 22 to 30 (inclusive) at screening
- CDR global score of 0.5 to 1.0 (inclusive), with a memory box score ≥0.5.
- Meet 18F flortaucipir positron emission tomography (PET) scan (central analysis) criteria
- Have a study partner who will provide written informed consent to participate
Age in the registry: 60 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (69)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Box Hill Hospital Coordinator of this site? Confirm its status | Box Hill | Australia | Unknown status |
| NeuroCentrix Coordinator of this site? Confirm its status | Carlton | Australia | Unknown status |
| Central Coast Neurosciences Research (Tumbi Umbi) Coordinator of this site? Confirm its status | Central Coast | Australia | Unknown status |
| Delmont Private Hospital Coordinator of this site? Confirm its status | Glen Iris | Australia | Unknown status |
| HammondCare Coordinator of this site? Confirm its status | Malvern | Australia | Unknown status |
| Private Practice - Dr PL Morris Coordinator of this site? Confirm its status | Southport | Australia | Unknown status |
| HammondCare Greenwich Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| St Vincent's Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| Hornsby Ku-Ring-Gai Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| KARA Institute for Neurological Diseases Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| The Queen Elizabeth Hospital Coordinator of this site? Confirm its status | Woodville | Australia | Unknown status |
| Ottawa Memory Clinic Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Bruyère Research Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Clinique de la Mémoire de l'Outaouais Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Diex Recherche Sherbrooke Inc. Coordinator of this site? Confirm its status | Sherbrooke | Canada | Unknown status |
| Toronto Memory Program Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Himeji Central Hospital Affiliated Clinic Coordinator of this site? Confirm its status | Himeji | Japan | Unknown status |
| Kobe City Medical Center General Hospital Coordinator of this site? Confirm its status | Kobe | Japan | Unknown status |
| KATAYAMA medical Clinic Coordinator of this site? Confirm its status | Kurashiki | Japan | Unknown status |
| Nozomi Memory Clinic Coordinator of this site? Confirm its status | Mitaka-shi | Japan | Unknown status |
| Kikukawa Clinic Coordinator of this site? Confirm its status | Nerima City | Japan | Unknown status |
| National Center for Geriatrics and Gerontology Coordinator of this site? Confirm its status | Ōbu | Japan | Unknown status |
| Memory Clinic Ochanomizu Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| Memory Clinic Toride Coordinator of this site? Confirm its status | Toride | Japan | Unknown status |
| Oita University Hospital Coordinator of this site? Confirm its status | Yufu | Japan | Unknown status |
| Podlaskie Centrum Psychogeriatrii Coordinator of this site? Confirm its status | Bialystok | Poland | Unknown status |
| Centrum Medyczne NEUROMED Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Unknown status |
| Centrum Badan Klinicznych PI-House sp. z o.o. Coordinator of this site? Confirm its status | Gdansk | Poland | Unknown status |
| Diamond Clinic Coordinator of this site? Confirm its status | Krakow | Poland | Unknown status |
| Nzoz Neuro-Kard Ilkowski i Partnerzy SPL Coordinator of this site? Confirm its status | Poznan | Poland | Unknown status |
| Centrum Medyczne SENIOR Coordinator of this site? Confirm its status | Sopot | Poland | Unknown status |
| Centrum Medyczne Euromedis Coordinator of this site? Confirm its status | Szczecin | Poland | Unknown status |
| Centrum Medyczne NeuroProtect Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
| Wroclawskie Centrum Alzheimerowskie Coordinator of this site? Confirm its status | Wroclaw | Poland | Unknown status |
| Abington Neurological Associates, Ltd Coordinator of this site? Confirm its status | Abington | United States | Unknown status |
| JEM Research Institute Coordinator of this site? Confirm its status | Atlantis | United States | Unknown status |
| VIN-Julie Schwartzbard Coordinator of this site? Confirm its status | Aventura | United States | Unknown status |
| The Memory Clinic Coordinator of this site? Confirm its status | Bennington | United States | Unknown status |
| Neurology Offices of South Florida Coordinator of this site? Confirm its status | Boca Raton | United States | Unknown status |
| University at Buffalo - UBMD Neurology Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Hope Clinical Research, Inc. Coordinator of this site? Confirm its status | Canoga Park | United States | Unknown status |
| Kerwin Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Brain Matters Research Coordinator of this site? Confirm its status | Delray Beach | United States | Unknown status |
| Rhode Island Mood & Memory Research Institute Coordinator of this site? Confirm its status | East Providence | United States | Unknown status |
| Neuropsychiatric Research Center of Southwest Florida Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| Neuro-Pain Medical Center Coordinator of this site? Confirm its status | Fresno | United States | Unknown status |
| The University of Texas Health Science Center at Houston Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Josephson Wallack Munshower Neurology, PC Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Irvine Clinical Research Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| K2 Medical Research Coordinator of this site? Confirm its status | Maitland | United States | Unknown status |
| ClinCloud - Viera Coordinator of this site? Confirm its status | Melbourne | United States | Unknown status |
| Merritt Island Medical Research, LLC Coordinator of this site? Confirm its status | Merritt Island | United States | Unknown status |
| VIN-Andrew Lerman Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| IMIC, Inc. Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| VIN-Victor Faradji Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Institute for Neurodegenerative Disorders Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Suncoast Clinical Research, Inc. Coordinator of this site? Confirm its status | New Port Richey | United States | Unknown status |
| Boston Center for Memory Coordinator of this site? Confirm its status | Newton | United States | Unknown status |
| Renstar Medical Research Coordinator of this site? Confirm its status | Ocala | United States | Unknown status |
| VIN- Margarita Almeida El-Ramey Coordinator of this site? Confirm its status | Pembroke Pines | United States | Unknown status |
| Donald S.Marks, M.D.,P.C. Coordinator of this site? Confirm its status | Plymouth | United States | Unknown status |
| Keystone Clinical Studies Coordinator of this site? Confirm its status | Plymouth Meeting | United States | Unknown status |
| Sharp Mesa Vista Hospital Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| The Cognitive and Research Center of New Jersey Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Brain Matters Research Coordinator of this site? Confirm its status | Stuart | United States | Unknown status |
| Charter Research - Lady Lake Coordinator of this site? Confirm its status | The Villages | United States | Unknown status |
| Advanced Memory Research Institute of New Jersey Coordinator of this site? Confirm its status | Toms River | United States | Unknown status |
| MedVadis Research Corporation Coordinator of this site? Confirm its status | Waltham | United States | Unknown status |
| Adams Clinical Coordinator of this site? Confirm its status | Watertown | United States | Unknown status |
Related publications
- Ceperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial.JAMA · 2026 · PMID 42441396
This page is information, not medical advice. Discuss any trial with your doctor.