Prediction of Aortic Dilatation and Rupture
Key facts
- Who runs it
- Kuopio University Hospital
- Where
- Finland1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 170 people enrolled
- Started
- 1 Jan 2017
- Ended
- 31 Dec 2024
- Type of study
- Observational, 3 groups
- Treatments tested
- Aortic MRI + 4D flow MRI
- Record updated
- 12 August 2025
Who can take part
- Age
- 18 years to 80 years
- Sex
- Women and men
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- aortic dilatation
- scheduled for imaging follow up in Kuopio University Hospital
- written informed concent
Who cannot take part
- lack of co-operation
- contraindications to MRI
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Aortic aneurysm is a very common incidental finding in the diagnostic imaging of the chest. It is especially common in middle aged men (up to 40 %). It is called as a silent killer, since it can lead to aortic dissection and rupture without pre-existing symptoms. Mortality of rupture can be up to 50 %. This is why it causes extensive human uncertainty and fear. Currently, there are no methods to identify the high risk patients. That leads to a practice where all patients are followed with repeated aortic imaging using expensive methods such as magnetic resonance imaging (MRI) and computed tomography.
Read full original descriptionShow less
There is data, that modern 4D flow MRI parameters well describe the intra-aortic flow conditions. This prospective clinical trial explore the value of 4D flow MRI parameters in the prediction of aortic dilatation and rupture. The trial consists of three subtrials in whitch the 4D flow MRI parameters are tested in clinical practice.
The 3 groups in the trial
- Different 4D flow MRI parameters in aortic dilatation and controls
Patients with aortic dilatation (n=20) scheduled for aortic MRI and healthy controls (n=20) without aortic dilatation. One time aortic MRI with 4D flow imaging.
Treatment: Aortic MRI + 4D flow MRI
- Value of aortic 4D flow MRI parameters to predict aortic dilatation in 5 years follow up
Patients with aortic dilatation (n=100) scheduled for aortic MRI follow up in Kuopio University Hospital. Aortic 4D flow MRI will be done yearly for 5 years and flow parameters predicting aortic dilatation will be analysed.
Treatment: Aortic MRI + 4D flow MRI
- Histology, molecular biology and genetics behind aortic dilatation
Patients scheduled for aortic operation (n=20+100) in Kuopio University Hospital. Aortic tissue samples and blood will be collected for analysis and compared to 4D flow MRI parameters. Control samples will be collected from healthy organ donors (n=5+5) operated in Kuopio University Hospital.
Treatment: Aortic MRI + 4D flow MRI
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Prediction of Aortic Dilation and Rupture in Different Predisposing Pathologies A Prospective Clinical Study
- Record updated
- 12 August 2025