Combined Flow and Pressure Study of Craniospinal Dynamic
Key facts
- Who runs it
- Centre Hospitalier Universitaire, Amiens
- Where
- France1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 75 people enrolled
- Started
- 4 Jan 2022
- Ended
- 24 Sept 2024
- Type of study
- Observational
- Treatments tested
- Flow MRI
- PERFUSION TEST
- Record updated
- 12 June 2026
Who can take part
- Age
- 55 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- age > 55 years
- Patients with suspected active hydrocephalus (HA) known as "normal pressure":
- Ventricular dilatation: Evans index > 0.3
- Patients with cognitive impairment, and/or gait disorders and/or urinary incontinence or a combination of these three symptoms
- Absence of other neurological diseases that could cause ventriculomegaly
- Information and collection of the patient's non opposition
Who cannot take part
- All individuals with implants, pacemakers, prostheses and ferromagnetic objects
- All patients with neurological disease other than active hydrocephalus will be excluded
- Individuals who cannot tolerate an MRI examination
- Patients under guardianship, curators or safeguard of justice
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Normal pressure hydrocephalus (NPH) can cause a type of dementia. However, this type of dementia is the only one that is reversible. To treat this dementia it is necessary to evacuate the accumulation of CSF from the brain to another body cavity using a device called a shunt. But the implantation of this shunt is only effective when the cause of the pathology is an alteration of the normal circulation of the CSF. To diagnose these patients, morphological MRI and lumbar puncture are standard approaches used but remain perfectible in diagnostic terms.
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The main objective is to build a new model of the interaction of intracranial pressures and fluids in order to obtain a new parameter allowing to obtain information on the cerebral biomechanics.
Treatments tested
- Flow MRI
- PERFUSION TEST
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Combined Flow-pressure Study of Cerebrospinal Circulation Using CSF Perfusion Tests and Phase-contrast MRI - Reversible Dementia Substudy
- Record updated
- 12 June 2026