Linfociti T virus-specifici per infezioni virali resistenti alla terapia farmacologica dopo trapianto allogenico di cellule staminali emopoietiche e in pazienti con grave immunodepressione primitiva o secondaria

Who can take part

• Allogeneic transplant with any cells source and conditioning regimen
• Presence of informed consent to the treatment of the patient / parent /legal guardian
• Age between 0-30 years
• Viral infection/reactivation (CMV, EBV, ADV, BK)
• Absence of concomitant severe uncontrolled infections
• Life expectancy exceeding 30 days
• Absence of acute or chronic uncontrolled Graft versus Host Disease (GvHD)
• Absence of acute kidney damage (creatinine value> 3 times the value normal with respect to age) not related to viral infection
• Absence of severe acute liver injury (direct bilirubin> 3mg / dl or glutamicoxaloacetic transaminase -SGOT> 500 UI/L) not related to viral infection

Who cannot take part

• Absence of a suitable donor (seronegativity for the virus in question and / or failure to respond to the secretion test)
• Patient with severe renal and/or hepatic impairment as specified above
• Primary or secondary graft failure
• Relapse of malignant underlying disease