Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
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- Who runs it
- Sunnybrook Health Sciences Centre
- Trial code
- NCT05079464
- Record updated
- 13 April 2026
- Original description
People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or "primed" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.Read full original descriptionShow less
Exercise as a Primer for Excitatory Stimulation Study in Vascular Cognitive Impairment No Dementia (EXPRESS-V)
People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or "primed" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.
Inclusion: ≥50 years of age; females must be post-menopausal; Presence of cerebrovascular and/or cardiovascular risk factors or coronary artery disease; Montreal Cognitive Assessment (MoCA) <27; Sufficiently proficient in English; Must be able to exercise at a moderate intensity level; Presence of modest deficits (1 standard deviation below population norm) in one of the following domains: executive function, verbal memory, working memory, or visuospatial memory.
Exclusion: Metal implants that would preclude safe use of tDCS or neuroimaging; History of stroke; Significant neurological or psychiatric conditions (current major depressive disorder, bipolar disorder, schizophrenia); MoCA <18 and/or clinical diagnosis of dementia; Change in psychotropics within the last 4 weeks; Current benzodiazepine use due; Any medical contraindications to exercise.