Imaging Brain Energy Metabolism With MRI in Glut1 Deficiency and Metabolic Disease
Tests an MRI method to measure brain energy use in people with Glut1 deficiency syndrome.
Plain-language title generated from the registry record
Registry title: Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and Metabolic Disease
Key facts
- Where
- Dallas and New York, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 16 and 80 years old?
Source: NCT05085704, who can take part
Where in United States
- UT Southwestern Medical CenterDallas, United StatesNo longer taking part
- Weill Cornell MedicineNew York, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Weill Medical College of Cornell University
- Trial code
- NCT05085704
- Record updated
- 1 June 2026
- Original description
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla or 3 Tesla.Read full original descriptionShow less
Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and Metabolic Disease
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla or 3 Tesla.
Inclusion: Subjects will be adolescents or adults, age 16-80 years in good general health (evidenced by normal vital signs and no acute signs or symptoms of illness) or with previously (not for this study) documented G1D (genetically confirmed); Ages 16 to 80; Persons with dental fillings, dental crowns, and short (max.4 cm) dental retainer wires can be included.
Exclusion: Subjects with typical implanted orthopedic metal in bone may be considered for inclusion in a 7T scan providing the implant is not within the volume of the radio frequency coil. The PI and the AIRC Medical Director will discuss each case and determine eligibility; Persons with questionable ferrous implants, bullets, BB's, and shrapnel will be excluded; People or patients with uncontrolled seizure disorder, defined as grand mal (not absence) seizure in the preceding 3 months; Pregnant females will be excluded. A serum or urine pregnancy test will be administered to all females of child bearing potential within 24 hours of administration of the tracer and MRI scan. The pregnancy test will be communicated in person by the study PI. Positive results in subjects 17 years old or younger will be disclosed to parent/guardian only; Persons with ICD, pacemakers, neurostimulators and other such devices will be excluded; Persons with claustrophobia are excluded; Subjects who are not fluent in English will be excluded because immediate cooperation and the ability to respond to instructions from the investigators are necessary; People following a ketogenic diet.