Follows adults hospitalised with acute breathing conditions and their recovery over time
Studies outcomes of adults admitted with sudden lung conditions, including COPD flare-ups.
Key facts
- Who runs it
- University of Leicester
- Where
- Leicester, United KingdomSee the site
- Trial code
- Registry title
- Study of Hospitalised Patients With Acute Respiratory Conditions
- Status
- Recruiting
- People taking part
- 500 people, planned
- Started
- 2 Feb 2022
- Expected to end
- 30 Oct 2033
- Type of study
- Observational, 2 groups
- Record updated
- 6 October 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults in hospital with a sudden breathing problem, adults followed in lung clinics for long-term lung disease, and healthy adults without lung disease.
- Age
- 18 Years to 90 Years
- Sex
- All sexes can join.
- Disease stage
- Admitted to hospital with a sudden (acute) breathing illness, or being treated in a hospital lung clinic for a long-term lung disease. A separate healthy group has no lung disease.
Main reasons for not taking part
- Unstable or life-threatening heart disease, including heart attack or unstable angina during the current hospital stay
- Any other serious illness that could put the person at risk or affect the results, in the investigator's opinion
- Known pregnancy
- Healthy group: hospitalised for an acute breathing illness in the 6 weeks before consent
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Hospital admission with an acute respiratory diagnosis, or currently under the care of hospital respiratory outpatient services for a chronic respiratory disease
- Participant is willing \& able to give informed consent for participation in the study
- Aged 18 years or above
- Able (in the Investigators opinion) \& willing to comply with all study requirements
- Aged 18 years or above
- No underlying respiratory disease as self-reported
- Able (in the Investigators opinion) \& willing to comply with all study requirements
Who cannot take part
- Hospitalised due to an acute respiratory illness in the last 6 weeks prior to consent
- Unstable or life-threatening cardiac disease including myocardial infarction or unstable angina during current admission
- Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study
- Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study
- Known pregnancy
- Known pregnancy; Additional inclusion and exclusion criteria for CHESTY sub-studies are detailed in the corresponding sub-study protocols
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Where in United Kingdom
- Glenfield HospitalLeicester, United KingdomContact: Jill ClanchyTaking people
About the trial
What the trial wants to find out
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand factors that may predict recovery, hospital readmission, length of hospital stay, and mortality. A group of people with chronic respiratory disease who are being followed in respiratory outpatient clinics and a healthy control group without lung disease will also take part.
Read full original descriptionShow less
The main questions it aims to answer are:
* Which clinical, physical, functional, and biological characteristics are associated with short-term outcomes after hospitalisation, including 30-day hospital readmission, length of hospital stay, and 30-day mortality? * Which characteristics are associated with longer-term recovery, future exacerbations, hospital readmissions, healthcare use, and mortality? * Can measurements taken during or around the time of hospitalisation be used to identify people at greater risk of poor outcomes who may benefit from targeted interventions?
Participants will undergo clinical assessments that may include questionnaires, measurements of physical function and muscle strength, lung function tests, physical activity monitoring, and collection of biological samples. Some participants may also undergo additional assessments of body composition, muscle size and function, imaging, or muscle metabolism, including through nested sub-studies. Participants will be followed for up to 36 months to assess recovery and longer-term clinical outcomes.
The 2 groups in the trial
- Hospitalised Patients
Participants admitted to hospital with an acute respiratory condition including exacerbation of an underlying physician diagnosed chronic lung disease.
- Matched Controls (stable COPD and healthy volunteers)
The study will include matched controls (non-hospitalised patients with stable chronic respiratory conditions or healthy volunteers) to compare the exploratory endpoints. The number of the matched controls will not exceed 25% of the main study recruitment.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Observational Cohort Study of Hospitalised Patients With Acute Respiratory Conditions
- Plain-language title
- Follows adults hospitalised with acute breathing conditions and their recovery over timeGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05095090, who can take part
- Record updated
- 6 October 2026