Tests weight loss surgery before knee replacement in people with severe obesity
Tests weight loss surgery before knee replacement in adults with severe obesity and knee arthritis.
Plain-language title generated from the registry record
Registry title: Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial
Key facts
- Where
- Halifax, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with severe knee osteoarthritis and a very high body weight. It studies weight loss surgery before knee replacement surgery.
- Age
- 18 Years to 65 Years
- Sex
- All sexes can join.
- Disease stage
- Severe knee osteoarthritis. Body-mass index of 45 to 60.
- Earlier treatment
- People cannot join if they had a total replacement of the same knee, or earlier bariatric or complex foregut surgery.
Main reasons for not taking part
- Need for replacement of both knees
- Knee pain in the past week rated higher than 60 mm on a 100-mm scale
- Significant heart, lung, kidney, liver, stomach or bowel, or psychiatric disorders
- Pregnancy
- Cancer within the last 5 years
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT05120492, who can take part
Where in Canada
- Nova Scotia HealthHalifax, CanadaContact: James Ellsmere, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Nova Scotia Health Authority
- Trial code
- NCT05120492
- Record updated
- 21 August 2024
- Original description
Does weight loss surgery in patients with morbid obesity prior to knee replacement surgery improve outcomes from knee replacement surgeryRead full original descriptionShow less
Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial
Does weight loss surgery in patients with morbid obesity prior to knee replacement surgery improve outcomes from knee replacement surgery
Inclusion: severe knee osteoarthritis body-mass index of 45 to 60.
Exclusion: previous total replacement of the same knee, a need for bilateral total knee replacement, and knee pain during the previous week that the patient rated at higher than 60 mm on a 100-mm visual-analogue scale. Also,prior bariatric or complex foregut surgery, significant cardiovascular, pulmonary, renal, liver, gastrointestinal, psychiatric disorders, pregnancy, malignancy within last 5 years, anemia, coagulopathy requiring anti-coagulation therapy.