NCT05132660Enrolling by invitationEarly phase 1
Treating Early Stage Diabetic Retinopathy
Source: ClinicalTrials.gov · Last updated 7 Apr 2026
Brief summary (registry, in English)
To determine if levodopa will slow the appearance of blood vessel changes in the eyes of patients with diabetes. Treatment will be started in patients with diabetes show delays in the electrical activity of the retina when measured non-invasively with a electroretinogram.
- Status (registry)
- Enrolling by invitation
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 244 (estimated)
- First submitted
- 22 Nov 2021
- Start date
- 1 Jul 2022
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Diabetic eye disease
- NCT number
- NCT05132660
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 244
- From 1 Jul 2022 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- No anti-VEGF or steroid treatments within the last 12 months
Other illness
- Patients with pituitary tumor, psychosis, Parkinson's disease
- Patients with confounding ocular disease (visually significant cataract, glaucoma, macular degeneration, retinitis pigmentosa)
Other
- Patients with cognitive deficits (score of 24 or less on the Montreal Cognitive
- Assessment-MOCA
- Pregnancy
Who the study is looking for
- HbA1c 8-12%
- Diabetic patients with no retinopathy as screened with teleretinal imaging
- Diabetic patients with microaneurysms as detected with fundus teleretinal screening
- ERG oscillatory potential delays in response to dim flash stimuli
Age in the registry: 30 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atlanta VA Medical and Rehab Center, Decatur, GA Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.