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Looking for myocarditis in adults with chest pain and no blocked heart arteries

Reviews records of adults with chest pain to find hidden myocarditis.

Key facts

Who runs it
Kansas City Heart Rhythm Research Foundation
Where
Austin, Loma Linda, Overland Park, and The Bronx, United StatesSee the 4 sites
Trial code
Registry title
The ORCHESTRATE-Myocarditis Registry
Status
Not yet recruiting
People taking part
382 people, planned
Started
Jan 2026
Planned end
May 2026
Type of study
Observational
Treatments tested
  • Imaging
Record updated
28 August 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who came to care with typical or atypical chest pain. Their heart tests found no blocked blood flow (ischemia). Past records are reviewed to look for heart muscle inflammation (myocarditis).

Age
Over 18 years
Sex
All sexes
Disease stage
Typical or atypical chest pain (ICD-10 Code R07.89, R07. 9) with a negative test for reduced heart blood flow.
Biomarker or test result
Heart tests such as Coronary Artery Calcium Scoring/CTA, MPI, Nuclear Stress test or LHC/angiography must show no more than "non-obstructive CAD".

Main reasons for not taking part

  • Heart tests show reduced blood flow as the cause of the chest pain
  • Past Prinzmetal angina or coronary vasospasm (spasm of the heart arteries)
  • Past heart attack or past coronary artery disease worse than "non-obstructive CAD" in all 3 coronary arteries
  • Past LVEF<40% (weak heart pumping)
  • Past pericarditis or costochondritis

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Age >18 years
  • Patients with a presentation of typical or atypical chest pain (ICD-10 Code R07.89, R07. 9)
  • Patients with a negative ischemic workup: (including Coronary Artery Calcium Scoring/CTA, MPI, Nuclear Stress test, LHC/angiography showing anything greater than "non-obstructive CAD")

Who cannot take part

  • Previously documented history of Prinzmetal angina or coronary vasospasm
  • History of prior myocardial infarction
  • History of any prior CAD with severity greater than "non-obstructive CAD" in all 3 coronary arteries
  • Previously documented history of pericarditis
  • Previously documented history of costochondritis
  • Patients with any evidence of positive ischemic workup as the cause of typical/atypical chest pain (as seen on Coronary Artery Calcium Scoring/CTA, MPI, Nuclear Stress test, LHC/angiography)
  • History of LVEF<40%

Where in United States

  • Texas Cardiac Arrhythmia Institute at St. David's Medical CenterAustin, United StatesContact: Andrea Natale, MDNot yet recruiting
  • Loma Linda University International Heart InstituteLoma Linda, United StatesContact: Jalaj Garg, MDNot yet recruiting
  • Kansas City Heart Rhythm InstituteOverland Park, United StatesContact: Dhanunjaya Lakkireddy, MDNot yet recruiting
  • Montefiore Medical CenterThe Bronx, United StatesContact: Luigi Di Biase, MDNot yet recruiting

About the trial

What the trial wants to find out

A retrospective, observational study consisting of patients who presents with typical/atypical chest pain and have an ensuing negative ischemic evaluation

The group in the trial

  • Patients with symptoms of typical/atypical chest pain

    Patients will be retrospectively included based on their presenting ICD codes or symptoms of typical/atypical chest pain, and those patients with positive ischemic workup will be excluded. The patients with negative ischemic workup will be included, and through chart review these patients will be followed to further assess their continued diagnostic workup.

    Treatment: Imaging

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Observational Registry of Ischemia Negative Chest Pain as the Presentation of Underlying Myocarditis: the ORCHESTRATE-Myocarditis Registry
Plain-language title
Looking for myocarditis in adults with chest pain and no blocked heart arteriesGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
28 August 2025