Fall Risk Assessment in a Population of Charcot-Marie-Tooth Disease Type 1A (CMT 1A) by Timed Up and Go Test
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Trial details
- Who runs it
- University Hospital, Clermont-Ferrand
- Trial code
- NCT05142059
- Record updated
- 27 December 2024
- Original description
The main objective of this study is to explore the relationship between the onset of fall and the time taken to complete the Timed Up and Go test (TUG) in this CMT1A patient population.Read full original descriptionShow less
The main objective of this study is to explore the relationship between the onset of fall and the time taken to complete the Timed Up and Go test (TUG) in this CMT1A patient population.
The investigators hypothesize that patients with balance disorders and therefore a risk of major fall will require a longer time to perform the Timed Up and Go test. In addition, it seems important to confirm that the severity of the disease has a negative impact on the frequency of balance disorders.
Inclusion: Patients older than 18 years; Diagnosis of Charcot Marie Tooth disease, type 1A confirmed by molecular biology (duplication 17.p11.2) and by a pathological electromyogram, that is to say with demyelinating impairment (+/- axonal) dependent length; Listening and written French; Strength of the quadriceps superior to 2/5 MMT MRC; Agreement after written information, clear and honest about the purpose of the study, the nature of the tests and their possible side effects or bothersome; Health insurance cover.
Exclusion: Presence of coronary artery disease unstabilized; Peripheral neuropathy of other causes: diabetes, monoclonal gammopathy, malignancy, solid cancer, systemic autoimmune disease (lupus, Sjögren's disease, Wegener sarcoidosis ...), infectious disease (viral hepatitis, HIV ...), drugs known to be responsible for iatrogenic neuropathy; Presence of other neurological comorbidity; Gait trouble of other origin; Patients unable to give their consent; Intellectual deficit that does not allow to comply with tests; Patient under guardianship, or protection of justice.