Deafness and Cognition in Middle-aged Adults
Key facts
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Where
- Paris, FranceSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 180 people, planned
- Started
- 24 May 2022
- Expected to end
- 24 May 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Cognitive and audiometry evaluation
- Record updated
- 15 September 2025
Who can take part
- Age
- 45 years to 64 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Cases: Patients aged between 45 to 64 years with severe to profound bilateral post-lingual sensorineural hearing loss with a maximum intelligibility of 70% (disyllabic words) in free-field silence with hearing aids at 60 dB SPL, current in french
- Controls: normal hearing subjects matched on age, sex and education level
Who cannot take part
- Psychotropic drug treatment
- Past and current history of neurological and psychiatric disorders including meningitis
- Associated disability that prevents the tests from being performed
- Vulnerable subject
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 64 years old?
Where in France
- Centre de Recherche en Audiologie (CReA) - Groupe Hospitalier Pitié-SalpêtrièreParis, FranceContact: Isabelle Dr MOSNIER, MDTaking people
About the trial
What the trial wants to find out
A mild cognitive impairment was observed in 50% of cochlear implant candidates aged 65 years and over, compared to 5-19% in general population. No studies analysed cognition in patients younger than 65 years. The aim of our study was to compare cognitive function between patients with severe and profound hearing loss and patients with normal hearing in patients aged 45 to 64 years.
The 2 groups in the trial
- Cases: Patients with severe to profound hearing lossTreatment being tested
Patients aged between 45 to 64 years with severe to profound bilateral post-lingual sensorineural hearing loss with a maximum intelligibility of 70% (disyllabic words) in free-field silence with hearing aids at 60 dB SPL
Treatment: Cognitive and audiometry evaluation
- Controls: 90 matched subjects with normal hearingExisting treatment, for comparison
Healthy controls aged between 45 to 64 years with normal hearing on pure-tone audiometry (as function of ISO 7029 reference)
Treatment: Cognitive and audiometry evaluation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Impact of Severe to Profound Deafness on Cognitive Functions in Middle-aged Adults
- Fit questions
- Built from NCT05149742, who can take part
- Record updated
- 15 September 2025