Taking people in United StatesNo phase
Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
Key facts
- Who runs it
- Massachusetts Eye and Ear Infirmary
- Where
- Boston, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 120 people, planned
- Started
- 21 Jun 2022
- Expected to end
- 31 Aug 2027
- Type of study
- Interventional
- Treatments tested
- Deep Brain Stimulation
- Record updated
- 2 December 2025
Who can take part
- Age
- 18 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 6 criteriaShow less
Other criteria
- Inclusion
- Clinical indications to proceed with DBS implantation, as determined by the clinical multidisciplinary movement disorders board, including: a) definitive diagnosis of essential tremor or dystonia, b) medically refractory disease, c) adequate performance on neuropsychological evaluation as determined by a licensed clinical neuropsychologist
- The ability to comply with test directions, complete pre-operative task training, and provide informed consent
- Age 18-80 years; Exclusion
- Inability to understand or perform the task outlined in the protocol during a pre-surgery training session. 2. Significant hearing loss
- Cortical venous anatomy that could potentially obstruct ECoG electrode placement, as determined by the surgeon, visualized on pre-op MRI or during surgery
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in United States
- Massachusetts General Hospital, University of California San Francisco, University of UtahBoston, United StatesContact: Kristina Simonyan, MD, PhDTaking people
About the trial
What the trial wants to find out
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.
The group in the trial
- Electrophysiological signal data collectionTreatment being tested
Patients diagnosed with dystonia or tremor who are recommended for DBS surgery. Electrophysiological data will be collected at the time of DBS surgery.
Treatment: Deep Brain Stimulation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT05150093, who can take part
- Record updated
- 2 December 2025