Mobile & Online-Based Interventions to Lessen Pain
Key facts
- Who runs it
- Stanford University
- Where
- Palo Alto, United StatesSee the site
- Trial code
- Status
- Completed
- Phase
- Phase 3
- People taking part
- 234 people enrolled
- Started
- 23 Aug 2023
- Ended
- 15 Aug 2025
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- Empowered Relief On-Demand
- Health Education
- Record updated
- 18 December 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Male and females 18 years of age or older
- Chronic non-cancer pain (at least 6 months in duration)
- Average pain intensity of at least 3 on the PROMIS SFV1.0 Pain Intensity 1a
- Daily prescription opioid use (at least 10 morphine milliequivalent daily dose; MEDD) for at least 3 months
- Opioid misuse (at least 6 on the Current Opioid Misuse Measure; COMM)
- English fluency
- Internet access
Who cannot take part
- Gross cognitive impairment
- Inability to complete study electronic surveys
- Cannot currently be enrolled in a study or trial with Empowered Relief as a treatment/intervention
Where in United States
- Stanford UniversityPalo Alto, United States
About the trial
What the trial wants to find out
The investigators will implement an international 2-arm online pragmatic feasibility randomized controlled trial (RCT) of a digital pain relief skills intervention "Empowered Relief: On-Demand" to reduce pain metrics, opioid craving, and opioid misuse. They will compare Empowered Relief to a no-skills digital health education ("Living Better") intervention in community-based individuals with comorbid chronic pain and prescription opioid misuse (N=220). Completion of the brief post-treatment survey is a binary measure of treatment engagement; treatment feasibility and appraisal are assessed with three items (satisfaction, perceived utility, and likelihood to use skills learned). Electronic surveys will measure opioid misuse behaviors, craving, and use; and pain intensity and psychological status at: baseline, immediately post-treatment; at post-treatment weeks 1 and 2; and months 1, 2, and 3.
The 2 groups in the trial
- Empowered Relief On DemandTreatment being tested
Empowered Relief On-Demand will include roughly 80 minutes of interactive and multimedia pain educational content that targets pain and stress self-regulation, pain medication misuse, a personalized plan for relief and an audio App for daily use.
- Health Education (HE; "Living Better")Placebo, for comparison
The HE arm is an interactive digital general health education intervention called "Living Better" that is devoid of specific content on pain, psychological skills, and has no active strategies or worksheets.
Treatment: Health Education
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Mobile & Online-Based Interventions to Lessen Pain (MOBILE Relief) in People With Prescription Opioid Misuse
- Record updated
- 18 December 2025