Tests electrical nerve stimulation for endometriosis-related chronic pain
Tests a nerve-stimulating device alongside usual pain medicine in adults with endometriosis pain.
Plain-language title generated from the registry record
Registry title: Transcutaneous Electrical Nerve Stimulation for Endometriosis-related Chronic Pain
Key facts
- Where
- Gothenburg, SwedenSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT05152264, who can take part
Where in Sweden
- Pain Centre, Department of Anaesthesiology and Intensive Care Medicine Östra, Sahlgrenska University Hospital, Region Västra GötalandGothenburg, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Göteborg University
- Trial code
- NCT05152264
- Record updated
- 23 May 2025
- Original description
The study evaluates the effect of TENS (transcutaneous electrical nerve stimulation) as add-on treatment compared with conventional analgesic treatment in patients with endometriosis-related chronic pain. Patients with frequent pain and high pain intensity will be randomized to additional treatment with TENS or conventional treatment for 8 weeks to evaluate the acute effects of TENS treatment (n=40). Patients with endometriosis-related pain that is not frequent or without high pain intensity constitute an external control group. All patients in the study will receive TENS treatment for a total of 16 weeks, for evaluation of long-term effects of TENS treatment.Read full original descriptionShow less
High Frequency, High Intensity Transcutaneous Electrical Nerve Stimulation for Endometriosis-related Chronic Pain - a Randomized Controlled Trial
The study evaluates the effect of TENS (transcutaneous electrical nerve stimulation) as add-on treatment compared with conventional analgesic treatment in patients with endometriosis-related chronic pain. Patients with frequent pain and high pain intensity will be randomized to additional treatment with TENS or conventional treatment for 8 weeks to evaluate the acute effects of TENS treatment (n=40). Patients with endometriosis-related pain that is not frequent or without high pain intensity constitute an external control group. All patients in the study will receive TENS treatment for a total of 16 weeks, for evaluation of long-term effects of TENS treatment.
Inclusion: Age ≥18 years; Consents to participation in the study; Verified endometriosis (by laparoscopy or ultrasound); Chronic endometriosis-related pain (> 3 months), available for TENS treatment; Functioning, stable endometriosis-specific hormonal drug therapy. The endometriosis-specific drug therapy must be unchanged for the last 3 months and no gynecological surgical procedures for the treatment of endometriosis are planned during the next 7 months (during study participation). The endometriosis-specific drug therapy does not refer to analgesic therapy for symptom relief of endometriosis-related pain.
Exclusion: Patient with pacemaker and/or ICD or other electronic implants; Malignant disease with an expected survival <12 months; Serious untreated psychiatric illness and/or psychological condition that is the primary determinant of the patient's condition; Patient with inability to understand and use written and spoken Swedish; Patient with impaired sensation over the painful area; Alcohol or substance abuse; Participating in another intervention study with possible impact on current study outcome measures; Patient who is using >90 morphine equivalents/day; Patient who is electro-acupuncture; Pregnancy.