Serotonin Role on Brain Circuits Involved in Food Avoidance in Anorexia Nervosa
Key facts
- Who runs it
- Centre Hospitalier Universitaire de Saint Etienne
- Where
- France1 site in 1 countryChoose a country to see its sites
- Status
- Terminated
- Phase
- Phase 3
- People taking part
- 57 people enrolled
- Started
- 10 Dec 2021
- Ended
- 8 Jul 2025
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- PET imaging using [11C]DASB radioligand.
- Eye Tracker
- Record updated
- 6 February 2026
- Why it stopped
- The sponsor received the following instruction from the ANSM : "The sponsor shall conduct toxicity studies in accordance with the applicable guidelines, in particular " ICH guideline M3 (R2) on non-clinical safety studies for the conduct of human cli
Who can take part
- Age
- 16 years to 35 years
- Sex
- Women only
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 16 criteriaShow less
Who can take part
- Anorexia nervosa common features : fear of weight gain, dysmorphophobia, BMI < 17.5 kg/ m², amenorrhea
- Absence of food compulsions and purges
- Subgroup 1 (15 subjects) : STAI Y2 anxiety score > 61
- Subgroup 2 (15 subjects) : STAI Y2 anxiety score < 51
- BMI between 18.5 and 25 kg/ m²
- Absence of a psychological profile of eating disorder or other psychiatric disorders
Who cannot take part
- Subject treated during the last three months with neuroleptics, and antiparkinsonian drugs, monoamine oxidase (MAO)-A or monoamine oxidase (MOA)-B inhibitors, tricyclic antidepressants, 5HT reuptake inhibitors, thymo regulators (lithium), antiepileptic dugs, codeine derivatives, morphinics, tramadol-containing products (Topalgic, …),dopaminergic drugs
- Subjects with suspected pregnancy; Test β human chorionic gonadotropin (HCG) positive prior to examination
- Subject with heart failure
- Subjects with an oral contraception and breastfeeding woman
- Subjects for whom MRI is contraindicated (pacemaker, intracerebral clips, prosthesis made of ferromagnetic material or claustrophobia)
- Subjects unable to sign written consent for participation in the study
- Subject deprived of liberty by a judicial or administrative decision
Other criteria
- Common Criteria for inclusion :
- Signature of written consent
- Subject affiliated or entitled to a social security scheme
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Serotoninergic activity in brain structures involved in food control and avoidance, such as the basal ganglia, is poorly understood in Anorexia Nervosa.
The 2 groups in the trial
- Anorexia Nervosa patientsTreatment being tested
30 patients with anorexia nervosa = 15 with moderate to high anxiety (STAI YB anxiety (STAI YB \> 51) and 15 with low anxiety (STAI YB\<51). A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2.
Treatment: PET imaging using [11C]DASB radioligand. and Eye Tracker
- ControlsPlacebo, for comparison
15 healthy volunteers (control group) and a low level of anxiety trait (\< 51) A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2.
Treatment: PET imaging using [11C]DASB radioligand. and Eye Tracker
Data and sources
- Registry record
- Listed on ClinicalTrials.gov and on the EU's official list of trials (CTIS).
- Official title
- Serotonin Role on Brain Circuits Involved in Food Avoidance in Anorexia Nervosa : Study of Gaze Control and Multimodal Brain Imaging
- Record updated
- 6 February 2026