Frontlight ResearchEarly access
CompletedPhase 3
Role of Doxycycline in Chronic Rhinosinusitis With Nasal Polyps
Key facts
- Who runs it
- Assiut University
- Where
- Egypt1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- Phase
- Phase 3
- People taking part
- 60 people enrolled
- Started
- 1 Jul 2021
- Ended
- 1 Jan 2024
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Doxycycline 100 mg Oral Tablet
- Prednisolone 20 mg
- Record updated
- 13 August 2024
Who can take part
- Age
- 18 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- 1- Adult patients (aged 18 and over) with bilateral nasal polyps confirmed by nasal endoscopy and CT scan
Who cannot take part
- If any major complications to the drugs in use appeared in process
- Subjects with known allergic reaction to steroids or tetracyclines, hypertension, diabetes (type 1 and 2), glaucoma, tuberculosis, herpes infection are excluded
- Patients younger than 18 years old
- CRS without nasal polyps
- Unilateral nasal polyps
- Pregnant and lactating women
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
To evaluate the efficacy of Doxycycline as an adjunct to systemic steroids in the treatment of chronic rhinosinusitis with nasal polyps
The 2 groups in the trial
- Steroids + DoxycyclineTreatment being tested
Systemic Prednisolone in decreasing doses (40 mg/d on days 1-7, 20 mg/d on days 8-14, and 10 mg/d on days 15-21) along with Doxycycline (200 mg as a loading dose on the 1st day, followed by 100 mg once daily one hour before meal as a maintenance dose) for 3 weeks.
Treatment: Doxycycline 100 mg Oral Tablet and Prednisolone 20 mg
- Steroids OnlyExisting treatment, for comparison
Systemic Prednisolone in decreasing doses (40 mg/d on days 1-7, 20 mg/d on days 8-14, and 10 mg/d on days 15-21) for 3 weeks.
Treatment: Prednisolone 20 mg
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Role of Doxycycline in the Management of Patients With Chronic Rhinosinusitis With Nasal Polyps
- Record updated
- 13 August 2024