WithdrawnNo phase
Oxygen-enhanced Magnetic Resonance Imaging (OE-MRI) of the Heart: A Feasibility Study
Key facts
- Who runs it
- Manchester University NHS Foundation Trust
- Where
- United Kingdom1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Withdrawn
- Started
- Jan 2023
- Ended
- Dec 2023
- Type of study
- Observational, 2 groups
- Treatments tested
- Oxygen-enhanced Cardiac MRI
- Record updated
- 2 February 2023
- Why it stopped
- Accumulated evidence (including data acquired in parallel studies, in other centres and in published literature) suggest that the technique was unlikely to produce a signal in the heart.
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
The registry criteria, word for word
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Who can take part
- 10 healthy volunteers and 10 patients with known significant (defined as > 70% stenosis) single or 2 vessel CAD
- Male or female > 18 years of age
- Females will be non-pregnant and non-lactating
Who cannot take part
- Patients taking Dipyridamole, or theophylline-based medication
- History of any significant lung disease including asthma and COPD
- History of type II respiratory failure
- Significant left main stem coronary artery disease
- Recent myocardial infarction (within 2 months)
- Unstable angina
- Abnormal heart rhythm e.g. atrial fibrillation, atrial flutter, atrial or ventricular bigeminy
- Pregnancy/breast-feeding. Women of childbearing potential (not >2 years post- menopausal and/or not surgically sterilised) must have a negative blood serum pregnancy test
- Contraindication to MRI (including claustrophobia)
- Second degree and higher atrio-ventricular conduction delay
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This exploratory pilot study aims to set up cardiac oxygen enhanced magnetic resonance imaging (OE-MRI). It will involve 10 healthy volunteers and 10 patients with known coronary artery disease (CAD) having a MRI scan.
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If positive, this data would be used to power an appropriately sized study assessing the utility of cardiac OE-MRI in CAD and other cardiac pathologies.
The 2 groups in the trial
- Healthy Volunteer
10 Volunteers (Male or Female), aged18 or over, with no known history of Coronary Artery Disease
Treatment: Oxygen-enhanced Cardiac MRI
- Known Coronary Artery Disease
10 Volunteers (Male orFemale), aged 18 or over,with a known significant (defined as =\> 70% stenosis) single or 2 vessel Coronary Artery Disease
Treatment: Oxygen-enhanced Cardiac MRI
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 2 February 2023