Comparing Breathing and Heart Responses to Blood-Flow Restricted Exercise in COPD
Compares heart and breathing responses to blood-flow restricted and standard exercise in adults with COPD.
Plain-language title generated from the registry record
Registry title: The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)
Key facts
- Where
- Zurich, SwitzerlandSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Source: NCT05163600, who can take part
Where in Switzerland
- University Hospital ZurichZurich, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Zurich
- Trial code
- NCT05163600
- Record updated
- 7 July 2026
- Original description
The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD.Read full original descriptionShow less
The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR):4 Randomized Crossover Studies
The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD.
Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.
Inclusion: Age ≥ 18 years; Clinically healthy; Age ≥ 18 years; Diagnosed COPD according to GOLD-guidelines12.
Exclusion: Physical or intellectual impairment precluding informed consent or protocol adherence; History of thromboembolic event in the lower extremity; Physical or intellectual impairment precluding informed consent or protocol adherence; History of thromboembolic event in the lower extremity; Non-German speaking (precluding informed consent); Pain during exercise of any origin; Pregnancy; Resting systolic blood pressure <100 mmHg; Inclusion and exclusion for the COPD participants are defined by the following criteria; Non-German speaking (precluding informed consent); Acute or recent (within the last 6 weeks) exacerbation of COPD; Pain during exercise of any origin; Pregnancy; Resting systolic blood pressure <100 mmHg.
Inclusion and exclusion for the healthy participants are defined by the following criteria.