Comparing Breathing and Heart Responses to Blood-Flow Restricted Exercise in COPD

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who are clinically healthy and adults with COPD. It compares how the heart and lungs react to exercise with and without blood-flow restriction.

Age

18 to 90 years

Sex

All sexes

Disease stage

Healthy participants, or COPD diagnosed according to the GOLD guidelines

Main reasons for not taking part

• Physical or intellectual impairment that prevents informed consent or following the protocol
• Does not speak German
• COPD flare-up now or within the last 6 weeks
• Pain during exercise of any origin
• Pregnancy

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 18 and 90 years old?YesNo

What the trial wants to find out

The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD.

The 4 groups in the trial

• Endurance Exercise - COPD and Healthy Participants (Fixed-Duration Protocol)Treatment being tested

  Both COPD patients and healthy participants will complete two endurance exercise conditions in a randomized, crossover design: * Blood Flow Restriction Cycling (BFR-CYC) * Non-BFR Control Cycling BFR-CYC: Three intervals of 2 minutes at 50% PWR, separated by 1-minute recovery periods, with bilateral thigh cuffs inflated to 50% LOP during exercise intervals. Control: Time- and structure-matched protocol (3 × 2 minutes) without blood flow restriction at 65% PWR, with identical recovery periods.

  Treatment: BFR-CYC 3x2min

• Resistance Exercise - COPD and Healthy Participants (BFR vs Control, Fixed Protocol)Treatment being tested

  Both COPD patients and healthy participants will complete two resistance exercise conditions in a randomized, crossover design: * Blood Flow Restriction Resistance Exercise (BFR-RE) * Non-BFR Control Resistance Exercise BFR-RE: Unilateral right-leg press at 40% of one-repetition maximum (1RM) with cuffs inflated to 80% LOP. Protocol: 4 sets (30-15-15-15 repetitions). Control: Bilateral leg press at 40% 1RM, 3 sets of 15 repetitions, without blood flow restriction.

  Treatment: BFR Resistance 80% LOP

• Endurance Exercise - COPD Participants (Exhaustive Protocol)Treatment being tested

  Patients with COPD will complete three cycling exercise conditions in a randomized, crossover design: * Blood Flow Restriction Cycling (BFR-CYC) * Continuous Cycling (CONT-CYC) * Interval Cycling (INT-CYC)

  Treatment: BFR-CYC 50% peak / 50% AOP (exhaustive)

• Resistance Exercise - Healthy Participants (LOP Comparison Arm)Treatment being tested

  Healthy participants will complete two BFR resistance exercise conditions in a randomized, crossover design: * BFR at 40% LOP * BFR at 80% LOP Participants will perform unilateral right-leg press exercise at 40% 1RM using a standardized protocol of 4 sets (30-15-15-15 repetitions) with fixed rest intervals. The protocol will be completed as prescribed (not to volitional exhaustion) unless predefined safety criteria require early termination.

  Treatment: BFR REsistance 48% vs. 80% LOP