Non-invasive spinal stimulation with gait training for walking after stroke
Tests non-invasive spinal cord stimulation with gait training in adults with stroke-related hemiplegia.
Plain-language title generated from the registry record
Registry title: Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
Key facts
- Where
- Chicago, United StatesSee the site
Where in United States
- Shirley Ryan AbilityLabChicago, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Shirley Ryan AbilityLab
- Trial code
- NCT05167786
- Record updated
- 20 October 2026
- Original description
This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.Read full original descriptionShow less
Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.
Inclusion: Age 18 years or older; Able and willing to give written consent and comply with study procedures; At least 6 months' post-stroke; Hemiplegia secondary to a single stroke; Functional Ambulation Category of 2 or greater - i.e., subject needs continuous or intermittent support of one person to help with balance and coordination; Not currently receiving regular physical therapy services; Physician approval to participate.
Exclusion: Orthopedic dysfunction, injury, or surgery that would impact an individual's ability to use the lower extremity; Metal implants in the head or face; Multiple stroke history; Using a powered, implanted cardiac device for monitoring or support of heart function (i.e. pacemaker, defibrillator, or LVAD) or anti-spasticity implantable pumps; Painful musculoskeletal dysfunction due to active injuries or infections; Medical illness limiting the ability to walk; Active urinary tract infection; Clinically significant depression, psychiatric disorders, or ongoing drug abuse; Active cancer or cancer in remission less than 5 years; Traumatic brain injury or other neurological conditions that would impact the study; TMS-Specific Exclusion Criteria: TMS will be utilized for both Aims. The sub-set of participants who meet these criteria will participate in this component of the studies; Implanted cardiac pacemaker; Had a seizure in the past unrelated to the stroke event, or has epilepsy; Unstable cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension, uncontrolled diabetes, or chronic emphysema); Ataxia; Botox injection in lower extremity within the last 4 months; Modified Ashworth score of 3 or greater in lower extremity; Pregnant or nursing; Active pressure sores; Unhealed bone fractures; Peripheral neuropathies; Severe contractures in the lower extremities; Medicated with agents known to increase (e.g., amphetamines) or decrease motor system excitability (e.g., lorazepam); Suffers unexplained, recurring headaches; Skull abnormalities or fractures; A concussion within the last 6 months.