Stopping Beta-Blockers in Heart Failure With Preserved Ejection Fraction
Tests stopping beta-blockers in adults with heart failure with preserved ejection fraction.
Plain-language title generated from the registry record
Registry title: Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
Key facts
- Where
- Farmington, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT05174351, who can take part
Where in United States
- UConn Health / John Dempsey HospitalFarmington, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- UConn Health
- Trial code
- NCT05174351
- Record updated
- 29 September 2025
- Original description
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.Read full original descriptionShow less
Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
Inclusion: Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100; N=30 (Target: 30); Age: 50 ~ 80 years; ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction; Chronic loop diuretic use; Currently on beta-blocker.
Exclusion: Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease; Heart rate > 100 bpm; Recent hospitalization due to HF within 3 months; Non-English speaker.