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Taking people in SwitzerlandNo phase

Imaging nerve fiber damage and repair in multiple sclerosis

Uses MRI scans to study nerve fiber damage in adults with multiple sclerosis.

Plain-language title generated from the registry record
Registry title: Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

Key facts

Where
Basel, SwitzerlandSee the site

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 80 years old?

Source: NCT05177523, who can take part

Where in Switzerland

  • University Hospital Basel, Department of NeurologyBasel, SwitzerlandTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
University Hospital, Basel, Switzerland
Trial code
NCT05177523
Record updated
16 December 2024
Original description
This project is to:Read full original descriptionShow less

INsIDER: Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

This project is to:

1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

Inclusion: Patients may be diagnosed with:; active RRMS (n=100): Relapsing-remitting course and > 1 clinical relapse and/or signs of MRI activity (> 1 Gd enhancing lesion) during the last year before study enrollment; non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment; Age 18-80 years old; No other neurological or psychiatric disorder; Age 18-80 years old; No other neurological or psychiatric disorder.

Exclusion: Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc); Pregnancy; Inability to give consent.

ClinicalTrials.gov NCT05177523