Project HOME: Home-Based Treatment Options and Mechanisms for Eating Disorders
Key facts
- Who runs it
- University of Pittsburgh
- Where
- Pawtucket and Pittsburgh, United StatesSee the 2 sites
- Trial code
- Status
- Completed
- People taking part
- 77 people enrolled
- Started
- 1 Aug 2022
- Ended
- 30 Apr 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Family-based treatment (FBT)
- Integrative family therapy
- Record updated
- 3 June 2026
Who can take part
- Age
- 12 years to 18 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Meets criteria for AN or atypical AN according to DSM-5 diagnostic criteria
- Currently living at home with caregivers who are willing to engage in family treatment
- Medically stable for outpatient treatment according to the recommended thresholds of the American Academy of Pediatrics and the Society of Adolescent Medicine (e.g., ≥75% of expected body weight, heartrate ≥50 beats per minute) and receiving medical monitoring from a clinician throughout treatment
- If on psychotropic medication, meets all eligibility criteria while on stable dose of psychotropic medication for a co-morbid condition
- Available for follow-up
Who cannot take part
- Current dependence on drugs or alcohol
- Concurrent involvement in other psychological treatment for an eating disorder
- Associated physical illness that necessitates hospitalization
- Psychotic illness/other mental illness requiring hospitalization
- Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
- Developmental delay that would preclude participation in the intervention
Where in United States
- Gateway HealthcarePawtucket, United States
- University of PittsburghPittsburgh, United States
About the trial
What the trial wants to find out
This randomized, controlled effectiveness trial will assess outcomes, implementation, and mechanisms of two psychological treatments for adolescent anorexia nervosa (AN) delivered in the home setting, in the context of community-based mental health. Adolescents with AN-spectrum disorders (n=50) and their caregivers will be randomly assigned to either family-based treatment or integrated family therapy delivered in the home. Caregivers and adolescents will provide data on weight, eating, and putative treatment mechanisms, including caregiver self-efficacy, adolescent distress, and generalizability of treatment skills. Treatment feasibility, acceptability, and appropriateness will be measured among providers and participating families. The proposed study has clear potential to advance scientific and clinical understanding of the real-world effectiveness of psychological treatments for AN, including whether adapting them for the home setting may improve accessibility and effects on treatment outcome
The 2 groups in the trial
- Family-based treatmentTreatment being tested
Families will complete 2-6 hours of therapy per week for 10 - 32 weeks, on average, determined by clinical need in conjunction with insurance specifications related to coverage of home-based care
Treatment: Family-based treatment (FBT)
- Integrative family therapyExisting treatment, for comparison
Families will complete 2-6 hours of therapy per week for 10 - 32 weeks, on average, determined by clinical need in conjunction with insurance specifications related to coverage of home-based care
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 3 June 2026