Testing airway germs in young children with asthma
Studies germ patterns in the airways of children under 3 with asthma.
Plain-language title generated from the registry record
Registry title: Respiratory Dysbiosis in Preschool Children with Asthma: Predictive of a Severe Form
Key facts
- Where
- Brest, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 3 years old?
Source: NCT05192499, who can take part
Where in France
- CHU de BrestBrest, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Brest
- Trial code
- NCT05192499
- Record updated
- 23 September 2024
- Original description
The prevalence of asthma in preschool children is between 11 and12%. Inhaled corticosteroid therapy is the main therapy used, however this treatment seems insufficiently effective in some children.Read full original descriptionShow less
Respiratory Dysbiosis in Preschool Children with Asthma: Predictive of a Severe Form
The prevalence of asthma in preschool children is between 11 and12%. Inhaled corticosteroid therapy is the main therapy used, however this treatment seems insufficiently effective in some children.
Recent research in cystic fibrosis has made it possible to highlight pulmotypes corresponding to the different stages of pulmonary dysbiosis, and a predictive microbiological signature of an increased risk of early primocolonization to P. aeruginosa. These pulmotypes are the result of the so-called "enterotyping" analysis, a biostatistical method that makes it possible to stratify individuals according to the analysis of the microbiota. In the light of these data, it seems interesting to transcribe the concept of using a biomarker of the microbiota in the monitoring of a chronic lung disease such as asthma.
The hypothesis is that there is respiratory dysbiosis causing corticosteroid resistance to treatment in children under 3 years of age with severe asthma.
Inclusion: Age greater than 1 year and less than 3 years; Diagnosis of asthma by a pediatrician; Parental consent; Affiliation to the social security system.
Exclusion: Recent antibiotic therapy (< 7 days); Treatment with oral corticosteroid therapy within the previous 10 days; Chronic pathologies: congenital heart disease, immune deficiency, cystic fibrosis, bronchopulmonary dysplasia, encephalopathy, primary ciliary dyskinesia, laryngomalacia, digestive pathology requiring digestive surgery; Premature < 34 SA; Patient whose parent(s) is (are) minor(s).