Tests brain stimulation with language tasks for speech loss after stroke
Tests 75Hz tACS during language exercises in adults with aphasia after stroke.
Plain-language title generated from the registry record
Registry title: Neurostimulation for the Treatment of Post-Stroke Aphasia
Key facts
- Where
- Chicago and New York, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT05194566, who can take part
Where in United States
- Think & Speak Lab at Shirley Ryan AbilityLabChicago, United StatesTaking people
- Abilities Research Center at Mount SinaiNew York, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- QVITI S.A.
- Trial code
- NCT05194566
- Record updated
- 18 February 2026
- Original description
The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.Read full original descriptionShow less
Neurostimulation for the Treatment of Post-Stroke Aphasia
The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.
Inclusion: diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist); presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT/MRI examination); chronic stage of the disease - time since the stroke occurred over 6 months; ability to achieve an accuracy in the Naming Task of 10-60%; 18-80 years; right-handedness before the stroke; ability to give informed written consent; fluency in English.
Exclusion: presence of metal implants in the skull; other previously absent neurological or mental symptoms; Withdrawal criteria:; other previously absent neurological, physical or mental symptoms; severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command; presence of major untreated or unstable psychiatric disease; history of epilepsy or seizures; ongoing medication that increases the risk of epileptic seizures; presence in the body of cardiac stimulator, pacemaker or vagus nerve stimulator (implanted); history of speech, language, hearing, or intellectual disability during childhood; occurrence of an epileptic seizure; occurrence of an epileptic seizure; pregnancy (based on declarations); high intolerance to stimulation; high intolerance to stimulation (participants experience severe discomfort during stimulation).
Individuals with aphasia (assessed using the Boston Diagnostic Aphasia Examination) who perform the Naming Task in the range of 10%-60% accuracy will be included in the study. The overall baseline score in the Naming Task will be estimated from the two baseline measurements.