MotIoN aDaptive Deep Brain Stimulation for MSA
Key facts
- Who runs it
- University of Oxford
- Where
- United Kingdom1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 3 people enrolled
- Started
- 3 Dec 2021
- Ended
- 1 Aug 2025
- Type of study
- Interventional
- Treatments tested
- Deep brain stimulation
- Record updated
- 17 November 2025
Who can take part
- Age
- 55 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Diagnosis of MSA with disabling autonomic symptoms
- >6/12 in the autonomic subsection (Q9-12) of the UMSAR scale
- Patient willing and able to give informed consent to involvement in the study
- Male or female aged 55 years or over
- Able to walk (to perform gait analysis)
- Have an anticipated prognosis > 2 years
Who cannot take part
- The patient has been deemed unfit for stimulator insertion by their healthcare team i.e. surgical contraindications to DBS:
- Unable to undergo preoperative MRI (e.g. metal implants)
- Bleeding or coagulation disorder
- Female of child-bearing age
- The patient is unwilling to participate or unable to give informed consent
- Not fit for general anaesthetic
- Unable to deal with implanted DBS system (turn on and off and recharging where applicable, although it is acceptable if a carer can do this)
- Untreated anxiety or depression
- Subject is currently participating in a clinical investigation that includes an active treatment arm
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), the effects on autonomic parameters such as blood pressure and bladder symptoms has been shown to be improved by the investigators (unpublished data). In this current study, the investigators plan to use a novel technique of adaptive DBS in order to provide stimulation dependent on patient physiological or positional factors. This is with the aim of making stimulation more responsive and patient-specific.
The group in the trial
- Deep brain stimulationTreatment being tested
All patients will undergo adaptive deep brain stimulation with results compared before and after stimulation
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 17 November 2025