Brain imaging to study chronic pain in people with cerebral palsy

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for people with cerebral palsy (CP), and people without a nerve or developmental condition, to study chronic pain using surveys and MRI brain scans.

Age

8 years and older.

Sex

All sexes.

Disease stage

People with CP can join the survey-only group. For the MRI group, brain scans must show injury only to the white matter near the brain's fluid spaces (periventricular white matter injury). All symptoms must come from this injury, and it must not be getting worse.

Biomarker or test result

For the CP MRI group: earlier clinical brain imaging showing isolated periventricular white matter injury.

Main reasons for not taking part

• People without CP who have a significant nerve or developmental diagnosis cannot join.
• People who cannot have an MRI cannot join the MRI groups.
• People who cannot lie still in the scanner for 1.5 hours cannot join the MRI groups.
• People without CP must be adults who can give their own consent to join the MRI group.

The registry criteria, word for word

What the trial wants to find out

The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.

The 4 groups in the trial

• Participants with CP (survey-only)

  Subjects in this group are age 8 and older with a diagnosis of cerebral palsy. Participants are either able to affirmatively consent or assent with LAR consent. This sample will have a CFCS score ranging between 1 and 3 and should be able to unambiguously respond to a 65 item multiple choice survey.

• Neurotypical participants (survey-only)

  Subjects in this group are age 8 and older with no clinically significant neurologic or developmental diagnosis. Participants are either able to affirmatively consent or assent with LAR consent.

• Participants with CP (Survey + MRI)

  Subjects are 8 years or older with a diagnosis of cerebral palsy and clinical imaging demonstrating isolated periventricular white matter injury. Clinical assessment states that neurologic symptoms are attributed to this isolated injury. Subjects in this group must be able to lie still in a scanner for 1.5 hours in at most 2 sessions and be able to have an MRI. Participants must be able to affirmatively consent or assent with LAR consent.

  Treatment: MRI

• Neurotypical participants (Survey + MRI)

  Subjects in this group are age 8 and older with no clinically significant neurologic or developmental diagnosis. Participants are able to affirmatively consent and are able to have an MRI. Subjects also should be able to lie still in a scanner for 1.5 hours.

  Treatment: MRI