Tests short high-dose radiotherapy before surgery for retroperitoneal sarcoma
Tests short, high-dose radiotherapy before surgery in adults with retroperitoneal sarcoma.
Plain-language title generated from the registry record
Registry title: Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01)
Key facts
- Where
- Beijing, ChinaSee the site
Where in China
- Radiotherapy Department of Cancer Hospital, Chinese Academy of Medical SciencesBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Trial code
- NCT05224934
- Record updated
- 11 December 2025
- Original description
To investigate the feasibility and peri-operative complications of preoperative hypo-fractionated radiotherapy followed by surgery for retroperitoneal sarcomaRead full original descriptionShow less
Full-target Ultra-hypofractionated Stereotactic Irradiation Orchestrated With Nodule Boost for Retroperitoneal Sarcoma
To investigate the feasibility and peri-operative complications of preoperative hypo-fractionated radiotherapy followed by surgery for retroperitoneal sarcoma
Inclusion: Primary soft tissue sarcoma of retroperitoneal or infra-peritoneal spaces of pelvis; Sarcoma not originated from bone structure, abdominal or gynecological viscera; All disease can be included safely within one radiotherapy field; Absence of extension through the sciatic notch or across the diaphragm; Histologically proven, excluding the following subtypes: Gastro-intestinal stromal tumors (GIST), rhabdomyosarcoma, PNET or other small round blue cells sarcoma, osteosarcoma or chondrosarcoma, aggressive fibromatosis, sarcomatoid or metastatic carcinoma; ECOG performance status 0 to 2; American Society of Anesthesiologist (ASA) score ≤2; Normal renal function: Calculated Creatinine Clearance ≥50ml/min（by Cockcroft-Gault formula）and functional contralateral kidney by differential renal isotope scan; Normal bone marrow and hepatic function; Contraception was needed for female patients of child-bearing age, or male patients whose partner had child-bearing age; expected life expectancy longer than 5 years; Written consent form was given prior to treatment; Can safely be treated by radiotherapy and surgery.
Exclusion: Tumor was previously treated by radiotherapy; metastatic disease; Involvement of liver, pancreatic head or duodenum.